Question 1

which of the following complement proteins does C-reactive protein interact?

Accepted Answer

A) factor D 
B) C1 
C) factor P 
D) C4 
E) C2. 
A) factor D 
B) C1 
C) factor P 
D) C4 
E) C2.

Question 2

Scavenger receptor SR-B recognizes _____.

Accepted Answer

A) lipopolysaccharides 
B) teichoic acid 
C) filamentous hemagglutinin 
D) CpG-rich bacterial DNA 
E) lipids. 
A) lipopolysaccharides 
B) teichoic acid 
C) filamentous hemagglutinin 
D) CpG-rich bacterial DNA 
E) lipids.

Question 3

Which of the following is not a characteristic of C-reactive protein?

Accepted Answer

A) acts as an opsonin by binding to phosphorylcholine of pathogens 
B) synthesized by spleen 
C) induced by elevated IL-6 levels 
D) a member of the pentraxin family 
E) triggers the classical pathway of complement activation. 
A) acts as an opsonin by binding to phosphorylcholine of pathogens 
B) synthesized by spleen 
C) induced by elevated IL-6 levels 
D) a member of the pentraxin family 
E) triggers the classical pathway of complement activation.

Question 4

Which of the following adaptor proteins participates in the activation pathway induced through either TLR3 or TLR4 that culminates in the synthesis of type I interferons?

Accepted Answer

A) C-reactive protein 
B) MyD88 
C) LPS-binding protein 
D) TRIF 
E) NF\kappaB. 
A) C-reactive protein 
B) MyD88 
C) LPS-binding protein 
D) TRIF 
E) NF\kappaB.

Question 5

In common with Toll-like receptors,NOD-like receptors also contain _____ that is/are used for pathogen-recognition of microbial ligands.

Accepted Answer

A) caspase-recruitment domains (CAR
D)  
B) Toll interleukin 1 receptor (TIR)domain 
C) variable extracellular domain 
D) leucine-rich repeat regions (LRRs) 
E) C-type lectin domain (CTL
D) . 
A) caspase-recruitment domains (CAR
D)  
B) Toll interleukin 1 receptor (TIR)domain 
C) variable extracellular domain 
D) leucine-rich repeat regions (LRRs) 
E) C-type lectin domain (CTL
D) .

Question 6

A.	What induces the production of type I interferon by virus-infected cells?
B.	Do normal cells produce this inducer? Why, or why not?
C.	Discuss the mechanisms by which type I interferons exert their antiviral effects.

Accepted Answer

A.Type I interferon genes (for interfero

Question 7

All of the following statements regarding Toll-like receptors are true except _____.

Accepted Answer

A) They exist as either transmembrane homodimers or heterodimers. 
B) The extracellular domain detects the microbial component. 
C) They facilitate changes in gene expression. 
D) They sense molecules not found in or on human cells. 
E) The cytoplasmic signaling domain contains a variable number of leucine-rich repeat regions (LRRs). 
A) They exist as either transmembrane homodimers or heterodimers. 
B) The extracellular domain detects the microbial component. 
C) They facilitate changes in gene expression. 
D) They sense molecules not found in or on human cells. 
E) The cytoplasmic signaling domain contains a variable number of leucine-rich repeat regions (LRRs).

Question 8

Unlike inflammatory cytokines,Toll-like receptors _____.

Accepted Answer

A) are never secreted 
B) participate only in adaptive immune responses 
C) are expressed only by dendritic cells 
D) stimulate the production of acute-phase proteins 
E) induce fever. 
A) are never secreted 
B) participate only in adaptive immune responses 
C) are expressed only by dendritic cells 
D) stimulate the production of acute-phase proteins 
E) induce fever.

Question 9

Which of the following TLRs do not use a signal transduction cascade involving MyD88?

Accepted Answer

A) TLR1:TLR2 
B) TLR3 
C) TLR4 
D) TLR2:TLR6 
E) TRL7. 
A) TLR1:TLR2 
B) TLR3 
C) TLR4 
D) TLR2:TLR6 
E) TRL7.

Question 10

Toll-like receptors differ from scavenger receptors in that they _____.

Accepted Answer

A) bind to common repetitive arrays on microbial surfaces 
B) stimulate a pathway that causes enzymatic degradation of the microbe to which they bind 
C) are soluble receptors that bind to microbes in extracellular spaces 
D) mediate signal transduction pathways,causing cytokine production. 
A) bind to common repetitive arrays on microbial surfaces 
B) stimulate a pathway that causes enzymatic degradation of the microbe to which they bind 
C) are soluble receptors that bind to microbes in extracellular spaces 
D) mediate signal transduction pathways,causing cytokine production.

Question 11

Match between columns
                        Premises: acute-phase response
respiratory burst
interferon response
apoptosis
extravasation

Accepted Answer

The Answer of temporary rise in oxygen consumption and toxic is...

Question 12

Sensors for viral nucleic acid in the cytoplasm,called RLRs,possess domains that bind to _____.

Accepted Answer

A) GTP-binding proteins 
B) type 1 interferons 
C) 5\prime-triphosphate of uncapped RNA 
D) oligomerized procaspase-1 
E) CARD domains of MAVS. 
A) GTP-binding proteins 
B) type 1 interferons 
C) 5\prime-triphosphate of uncapped RNA 
D) oligomerized procaspase-1 
E) CARD domains of MAVS.

Question 13

Immediately after engagement of NK-cell Toll-like receptors,the NK cell _____.

Accepted Answer

A) discharges cytotoxic granules 
B) ligates IL-12R\beta1 and IL-12R\beta 2 
C) synthesizes and secretes IL-15 
D) synthesizes and secretes IL-12 
E) synthesizes and secretes type I interferons. 
A) discharges cytotoxic granules 
B) ligates IL-12R\beta1 and IL-12R\beta 2 
C) synthesizes and secretes IL-15 
D) synthesizes and secretes IL-12 
E) synthesizes and secretes type I interferons.

Question 14

Measurement of which of the following is commonly used when monitoring patients with autoimmune diseases as an indicator of inflammatory relapse?

Accepted Answer

A) IL-1RA 
B) cryopyrin 
C) C-reactive protein 
D) proIL-1\beta 
E) IL-15. 
A) IL-1RA 
B) cryopyrin 
C) C-reactive protein 
D) proIL-1\beta 
E) IL-15.

Question 15

Match between columns
                        Premises: protein kinase R (PKR)
oligoadenylate synthetase
NK-cell synapse
RIG-I-like helicase
plasmacytoid dendritic cell (PDC)

Accepted Answer

The Answer of facilitates adhesion and information exchange between cells is...

Question 16

What is the name given to the earliest intracellular vesicle that contains material opsonized by macrophages?

Accepted Answer

A) opsonome 
B) membrane-attack complex 
C) lysosome 
D) phagosome 
E) phagolysosome. 
A) opsonome 
B) membrane-attack complex 
C) lysosome 
D) phagosome 
E) phagolysosome.

Question 17

Identify which of the following receptors does not lead to nuclear translocation of NF\kappaB through an activated IKK intermediate.

Accepted Answer

A) TLR4 
B) IL-1 receptor 
C) NOD1 
D) NOD2 
E) All of the above receptors culminate in nuclear translocation of NF\kappaB through an activated IKK intermediate. 
A) TLR4 
B) IL-1 receptor 
C) NOD1 
D) NOD2 
E) All of the above receptors culminate in nuclear translocation of NF\kappaB through an activated IKK intermediate.

Question 18

_____ is a cytokine produced by both macrophages and dendritic cells that promotes the proliferation,differentiation,and survival of NK cells.

Accepted Answer

A) IL-15 
B) IL-1\beta 
C) CXCL8 
D) TNF-\alpha 
E) IL-6. 
A) IL-15 
B) IL-1\beta 
C) CXCL8 
D) TNF-\alpha 
E) IL-6.

Question 19

Of the following Toll-like receptors,which is the most highly conserved and displays the smallest amount of allelic polymorphism?

Accepted Answer

A) TLR1 
B) TLR8 
C) TLR10 
D) TLR6 
E) TLR4. 
A) TLR1 
B) TLR8 
C) TLR10 
D) TLR6 
E) TLR4.

Question 20

_____ is not an opsonin.

Accepted Answer

A) Mannose-binding lectin 
B) IFN-\alpha 
C) C-reactive protein 
D) surfactant protein-A (SP-
A)  
E) surfactant protein-D (SP-
D) . 
A) Mannose-binding lectin 
B) IFN-\alpha 
C) C-reactive protein 
D) surfactant protein-A (SP-
A)  
E) surfactant protein-D (SP-
D) .

which of the following complement proteins does C-reactive protein interact?

Scavenger receptor SR-B recognizes _____.

Which of the following is not a characteristic of C-reactive protein?

Which of the following adaptor proteins participates in the activation pathway induced through either TLR3 or TLR4 that culminates in the synthesis of type I interferons?

In common with Toll-like receptors,NOD-like receptors also contain _____ that is/are used for pathogen-recognition of microbial ligands.

A. What induces the production of type I interferon by virus-infected cells? B. Do normal cells produce this inducer? Why, or why not? C. Discuss the mechanisms by which type I interferons exert their antiviral effects.

All of the following statements regarding Toll-like receptors are true except _____.

Unlike inflammatory cytokines,Toll-like receptors _____.

Which of the following TLRs do not use a signal transduction cascade involving MyD88?

Toll-like receptors differ from scavenger receptors in that they _____.

Sensors for viral nucleic acid in the cytoplasm,called RLRs,possess domains that bind to _____.

Immediately after engagement of NK-cell Toll-like receptors,the NK cell _____.

Measurement of which of the following is commonly used when monitoring patients with autoimmune diseases as an indicator of inflammatory relapse?

What is the name given to the earliest intracellular vesicle that contains material opsonized by macrophages?

Identify which of the following receptors does not lead to nuclear translocation of NF\kappaB through an activated IKK intermediate.

_____ is a cytokine produced by both macrophages and dendritic cells that promotes the proliferation,differentiation,and survival of NK cells.

Of the following Toll-like receptors,which is the most highly conserved and displays the smallest amount of allelic polymorphism?

_____ is not an opsonin.

Elements of the Immune System and Their Roles in Defense

Innate Immunity: the Immediate Response to Infection

Antibody Structure and the Generation of B-Cell Diversity

Antigen Recognition by T Lymphocytes

The Development of B Lymphocytes

The Development of T Lymphocytes

T Cell-Mediated Immunity

Immunity Mediated by B Cells and Antibodies

Preventing Infection at Mucosal Surfaces

Immunological Memory and Vaccination

Coevolution of Innate and Adaptive Immunity

Failures of the Bodys Defenses

Ige-Mediated Immunity and Allergy

Transplantation of Tissues and Organs

Disruption of Healthy Tissue by the Adaptive Immune Response

Cancer and Its Interactions With the Immune System

Filters

Exam 3: Innate Immunity: the Induced Response to Infection

which of the following complement proteins does C-reactive protein interact?

Scavenger receptor SR-B recognizes _____.

Which of the following is not a characteristic of C-reactive protein?

Which of the following adaptor proteins participates in the activation pathway induced through either TLR3 or TLR4 that culminates in the synthesis of type I interferons?

In common with Toll-like receptors,NOD-like receptors also contain _____ that is/are used for pathogen-recognition of microbial ligands.

A. What induces the production of type I interferon by virus-infected cells? B. Do normal cells produce this inducer? Why, or why not? C. Discuss the mechanisms by which type I interferons exert their antiviral effects.

All of the following statements regarding Toll-like receptors are true except _____.

Unlike inflammatory cytokines,Toll-like receptors _____.

Which of the following TLRs do not use a signal transduction cascade involving MyD88?

Toll-like receptors differ from scavenger receptors in that they _____.

Sensors for viral nucleic acid in the cytoplasm,called RLRs,possess domains that bind to _____.

Immediately after engagement of NK-cell Toll-like receptors,the NK cell _____.

Measurement of which of the following is commonly used when monitoring patients with autoimmune diseases as an indicator of inflammatory relapse?

What is the name given to the earliest intracellular vesicle that contains material opsonized by macrophages?

Identify which of the following receptors does not lead to nuclear translocation of NF\kappaB through an activated IKK intermediate.

_____ is a cytokine produced by both macrophages and dendritic cells that promotes the proliferation,differentiation,and survival of NK cells.

Of the following Toll-like receptors,which is the most highly conserved and displays the smallest amount of allelic polymorphism?

_____ is not an opsonin.

Elements of the Immune System and Their Roles in Defense

Innate Immunity: the Immediate Response to Infection

Antibody Structure and the Generation of B-Cell Diversity

Antigen Recognition by T Lymphocytes

The Development of B Lymphocytes

The Development of T Lymphocytes

T Cell-Mediated Immunity

Immunity Mediated by B Cells and Antibodies

Preventing Infection at Mucosal Surfaces

Immunological Memory and Vaccination

Coevolution of Innate and Adaptive Immunity

Failures of the Bodys Defenses

Ige-Mediated Immunity and Allergy

Transplantation of Tissues and Organs

Disruption of Healthy Tissue by the Adaptive Immune Response

Cancer and Its Interactions With the Immune System

Filters