Question 1

Which of the following are correctly matched? (Select all that apply.)

Accepted Answer

A) protein F; fibronectin 
B) neutralization; IgE 
C) breast milk; IgG 
D) influenza; hemagglutinin 
E) mucosal epithelium; IgA. 
A) protein F; fibronectin 
B) neutralization; IgE 
C) breast milk; IgG 
D) influenza; hemagglutinin 
E) mucosal epithelium; IgA.

Question 2

Bacteria use _____ to attach to the surface of cells during colonization.

Accepted Answer

A) hemagglutinins 
B) toxins 
C) breakdown products 
D) anti-inflammatory molecules 
E) adhesins. 
A) hemagglutinins 
B) toxins 
C) breakdown products 
D) anti-inflammatory molecules 
E) adhesins.

Question 3

The Igα-associated tyrosine kinase _____ phosphorylates the cytoplasmic tail of CD19,which mediates signal transduction in activated B cells.

Accepted Answer

A) CD81 
B) Blk 
C) Fyn 
D) Lyn 
E) Syk. 
A) CD81 
B) Blk 
C) Fyn 
D) Lyn 
E) Syk.

Question 4

From an immunological viewpoint,why would it be inadvisable for a mother who has recently given birth to move with her newborn to a foreign country where there are endemic diseases not prevalent in her homeland?

Accepted Answer

Newborn infants are afforded passive imm

Question 5

A distinguishing feature of FcγRIIB1 compared with FcγRIIA is _____.

Accepted Answer

A) its ability to activate cells and induce endocytosis 
B) the existence of ITIMs in its cytoplasmic tails 
C) its inability to bind to IgG1 
D) its expression on NK cells. 
A) its ability to activate cells and induce endocytosis 
B) the existence of ITIMs in its cytoplasmic tails 
C) its inability to bind to IgG1 
D) its expression on NK cells.

Question 6

_____ in the switch regions positioned 5′ to each heavy-chain C gene is induced by _____.

Accepted Answer

A) Somatic hypermutation; TI antigens 
B) Chromatin remodeling; B-cell co-receptor signaling 
C) Recombination; survival signals received from follicular dendritic cells 
D) Transcription; helper T-cell cytokines 
E) Gene repression; apoptotic signals received from tingible body macrophages. 
A) Somatic hypermutation; TI antigens 
B) Chromatin remodeling; B-cell co-receptor signaling 
C) Recombination; survival signals received from follicular dendritic cells 
D) Transcription; helper T-cell cytokines 
E) Gene repression; apoptotic signals received from tingible body macrophages.

Question 7

IgM is particularly efficient at fixing complement because it _____.

Accepted Answer

A) is a much larger antibody than the other isotypes 
B) has an extra CH domain 
C) is made first in an immune response and therefore has first access to C1q 
D) has five binding sites for C1q 
E) has easy access to extravascular areas. 
A) is a much larger antibody than the other isotypes 
B) has an extra CH domain 
C) is made first in an immune response and therefore has first access to C1q 
D) has five binding sites for C1q 
E) has easy access to extravascular areas.

Question 8

How does IgE induce the forcible ejection of parasites and toxic substances from the respiratory and gastrointestinal tracts?

Accepted Answer

When IgE binds to antigen,leading to cro

Question 9

Lymphoblasts upregulate a transcription factor called _____ when they terminally differentiate into plasma cells.

Accepted Answer

A) NFκB 
B) Bcl-xL 
C) B-lymphocyte induced maturation protein 1 (BLIMP-1) 
D) CD40 
E) ICAM-1. 
A) NFκB 
B) Bcl-xL 
C) B-lymphocyte induced maturation protein 1 (BLIMP-1) 
D) CD40 
E) ICAM-1.

Question 10

Match between columns
                        Premises: tingible body macrophage
follicular dendritic cells (FDC)
naive B cell
memory B cell
centroblast

Accepted Answer

The Answer of differentiate under the influence of an IL-4-secreting is...

Question 11

C3 convertase of the classical pathway is _____,whereas C3 convertase of the alternative pathway is _____.

Accepted Answer

A) C1a; C3bBb 
B) C4bC2a; C3bBb 
C) C3bCR1; C3bBb 
D) C4bC2a; C3bCR1 
E) C1a; C3bCR1. 
A) C1a; C3bBb 
B) C4bC2a; C3bBb 
C) C3bCR1; C3bBb 
D) C4bC2a; C3bCR1 
E) C1a; C3bCR1.

Question 12

Plasma cells and memory B cells differentiate most immediately from _____.

Accepted Answer

A) centrocytes 
B) centroblasts 
C) B-1 cells 
D) IgG-secreting B cells. 
A) centrocytes 
B) centroblasts 
C) B-1 cells 
D) IgG-secreting B cells.

Question 13

Describe the course of events that results in the swollen lymph nodes characteristic of many infections.Use the following terms in your

Accepted Answer

B lymphoblasts that have bound specific

Question 14

Complexes of IgG bound to soluble multivalent antigens can activate the classical pathway of complement,resulting in the deposition of _____ on the complex,targeting it for endocytic uptake by cells bearing _____.

Accepted Answer

A) C4b; CR2 and Fc receptors 
B) C3b; CR2 and Toll-like receptors 
C) C5-9; CR1 and Fc receptors 
D) C3b; CR1 and Fc receptors 
E) C2a; CR2 and Toll-like receptors. 
A) C4b; CR2 and Fc receptors 
B) C3b; CR2 and Toll-like receptors 
C) C5-9; CR1 and Fc receptors 
D) C3b; CR1 and Fc receptors 
E) C2a; CR2 and Toll-like receptors.

Question 15

C3d and iC3b are breakdown products of _____,which binds to _____ of the B-cell co-receptor.

Accepted Answer

A) C3a; CR2 
B) C3b; CR2 
C) C3c; CD81 
D) C3c; CD19 
E) C3b; CD19. 
A) C3a; CR2 
B) C3b; CR2 
C) C3c; CD81 
D) C3c; CD19 
E) C3b; CD19.

Question 16

A primary focus forms after a circulating naive B cell forms a conjugate pair with _____ in the _____ of a lymph node.

Accepted Answer

A) TH1 cell; B-cell zone 
B) cytotoxic T cell; T-cell zone 
C) follicular dendritic cell; germinal center 
D) TFH; medullary cords 
E) CD40 ligand; T-cell zone. 
A) TH1 cell; B-cell zone 
B) cytotoxic T cell; T-cell zone 
C) follicular dendritic cell; germinal center 
D) TFH; medullary cords 
E) CD40 ligand; T-cell zone.

Question 17

Which of the following antibodies activate the classical pathway of complement? (Select all that apply.)

Accepted Answer

A) IgM 
B) IgG1 
C) IgD 
D) IgG3 
E) IgE. 
A) IgM 
B) IgG1 
C) IgD 
D) IgG3 
E) IgE.

Question 18

What is the fate of centrocytes in which somatic hypermutation has resulted in high-affinity receptors for antigen? (Select all that apply.)

Accepted Answer

A) They die by apoptosis. 
B) They express Bcl-xL. 
C) They process antigen and present it to TFH cells. 
D) CD40 on the centrocyte engages with CD40 ligand on TFH cells. 
E) They undergo phagocytosis by tingible body macrophages. 
A) They die by apoptosis. 
B) They express Bcl-xL. 
C) They process antigen and present it to TFH cells. 
D) CD40 on the centrocyte engages with CD40 ligand on TFH cells. 
E) They undergo phagocytosis by tingible body macrophages.

Question 19

Explain why expression of CD40 ligand by TFH cells is important in the boundary area of primary follicles in secondary lymphoid tissue as it relates to the targeted delivery of secreted cytokines to the B-cell surface.

Accepted Answer

CD40 ligand on T_FH cells binds to CD40 on

Question 20

Which of the following are characteristics of systemic lupus erythematosus? (Select all that apply.)

Accepted Answer

A) It is an autoimmune disease. 
B) It is associated with a deficiency of C4A. 
C) Increased levels of immune complexes are detected in the blood. 
D) CR1 receptor levels are decreased. 
E) Immune complexes are deposited on the kidney glomeruli,which can lead to kidney complications. 
A) It is an autoimmune disease. 
B) It is associated with a deficiency of C4A. 
C) Increased levels of immune complexes are detected in the blood. 
D) CR1 receptor levels are decreased. 
E) Immune complexes are deposited on the kidney glomeruli,which can lead to kidney complications.

Which of the following are correctly matched? (Select all that apply.)

Bacteria use _____ to attach to the surface of cells during colonization.

The Igα-associated tyrosine kinase _____ phosphorylates the cytoplasmic tail of CD19,which mediates signal transduction in activated B cells.

From an immunological viewpoint,why would it be inadvisable for a mother who has recently given birth to move with her newborn to a foreign country where there are endemic diseases not prevalent in her homeland?

A distinguishing feature of FcγRIIB1 compared with FcγRIIA is _____.

_ in the switch regions positioned 5′ to each heavy-chain C gene is induced by _.

IgM is particularly efficient at fixing complement because it _____.

How does IgE induce the forcible ejection of parasites and toxic substances from the respiratory and gastrointestinal tracts?

Lymphoblasts upregulate a transcription factor called _____ when they terminally differentiate into plasma cells.

C3 convertase of the classical pathway is _,whereas C3 convertase of the alternative pathway is _.

Plasma cells and memory B cells differentiate most immediately from _____.

Describe the course of events that results in the swollen lymph nodes characteristic of many infections.Use the following terms in your

Complexes of IgG bound to soluble multivalent antigens can activate the classical pathway of complement,resulting in the deposition of _ on the complex,targeting it for endocytic uptake by cells bearing _.

C3d and iC3b are breakdown products of _,which binds to _ of the B-cell co-receptor.

A primary focus forms after a circulating naive B cell forms a conjugate pair with _ in the _ of a lymph node.

Which of the following antibodies activate the classical pathway of complement? (Select all that apply.)

What is the fate of centrocytes in which somatic hypermutation has resulted in high-affinity receptors for antigen? (Select all that apply.)

Explain why expression of CD40 ligand by T_FH cells is important in the boundary area of primary follicles in secondary lymphoid tissue as it relates to the targeted delivery of secreted cytokines to the B-cell surface.

Which of the following are characteristics of systemic lupus erythematosus? (Select all that apply.)

Elements of the Immune System and Their Roles in Defense

Innate Immunity: the Immediate Response to Infection

Innate Immunity: the Induced Response to Infection

Antibody Structure and the Generation of B-Cell Diversity

Antigen Recognition by T Lymphocytes

The Development of B Lymphocytes

The Development of T Lymphocytes

T Cell-Mediated Immunity

Preventing Infection at Mucosal Surfaces

Immunological Memory and Vaccination

Coevolution of Innate and Adaptive Immunity

Failures of the Bodys Defenses

Ige-Mediated Immunity and Allergy

Transplantation of Tissues and Organs

Disruption of Healthy Tissue by the Adaptive Immune Response

Cancer and Its Interactions With the Immune System

Filters

Exam 9: Immunity Mediated by B Cells and Antibodies

Which of the following are correctly matched? (Select all that apply.)

Bacteria use _____ to attach to the surface of cells during colonization.

The Igα-associated tyrosine kinase _____ phosphorylates the cytoplasmic tail of CD19,which mediates signal transduction in activated B cells.

From an immunological viewpoint,why would it be inadvisable for a mother who has recently given birth to move with her newborn to a foreign country where there are endemic diseases not prevalent in her homeland?

A distinguishing feature of FcγRIIB1 compared with FcγRIIA is _____.

_____ in the switch regions positioned 5′ to each heavy-chain C gene is induced by _____.

IgM is particularly efficient at fixing complement because it _____.

How does IgE induce the forcible ejection of parasites and toxic substances from the respiratory and gastrointestinal tracts?

Lymphoblasts upregulate a transcription factor called _____ when they terminally differentiate into plasma cells.

C3 convertase of the classical pathway is _____,whereas C3 convertase of the alternative pathway is _____.

Plasma cells and memory B cells differentiate most immediately from _____.

Describe the course of events that results in the swollen lymph nodes characteristic of many infections.Use the following terms in your

Complexes of IgG bound to soluble multivalent antigens can activate the classical pathway of complement,resulting in the deposition of _____ on the complex,targeting it for endocytic uptake by cells bearing _____.

C3d and iC3b are breakdown products of _____,which binds to _____ of the B-cell co-receptor.

A primary focus forms after a circulating naive B cell forms a conjugate pair with _____ in the _____ of a lymph node.

Which of the following antibodies activate the classical pathway of complement? (Select all that apply.)

What is the fate of centrocytes in which somatic hypermutation has resulted in high-affinity receptors for antigen? (Select all that apply.)

Explain why expression of CD40 ligand by TFH cells is important in the boundary area of primary follicles in secondary lymphoid tissue as it relates to the targeted delivery of secreted cytokines to the B-cell surface.

Which of the following are characteristics of systemic lupus erythematosus? (Select all that apply.)

Elements of the Immune System and Their Roles in Defense

Innate Immunity: the Immediate Response to Infection

Innate Immunity: the Induced Response to Infection

Antibody Structure and the Generation of B-Cell Diversity

Antigen Recognition by T Lymphocytes

The Development of B Lymphocytes

The Development of T Lymphocytes

T Cell-Mediated Immunity

Preventing Infection at Mucosal Surfaces

Immunological Memory and Vaccination

Coevolution of Innate and Adaptive Immunity

Failures of the Bodys Defenses

Ige-Mediated Immunity and Allergy

Transplantation of Tissues and Organs

Disruption of Healthy Tissue by the Adaptive Immune Response

Cancer and Its Interactions With the Immune System

Filters

_ in the switch regions positioned 5′ to each heavy-chain C gene is induced by _.

C3 convertase of the classical pathway is _,whereas C3 convertase of the alternative pathway is _.

Complexes of IgG bound to soluble multivalent antigens can activate the classical pathway of complement,resulting in the deposition of _ on the complex,targeting it for endocytic uptake by cells bearing _.

C3d and iC3b are breakdown products of _,which binds to _ of the B-cell co-receptor.

A primary focus forms after a circulating naive B cell forms a conjugate pair with _ in the _ of a lymph node.

Explain why expression of CD40 ligand by T_FH cells is important in the boundary area of primary follicles in secondary lymphoid tissue as it relates to the targeted delivery of secreted cytokines to the B-cell surface.