Exam 19: Ribosomes and Transfer Rna

Upon binding to a ribosome,an aminoacyl-tRNA first enters in the A/T with its anticodon in the decoding site of the 30S particle and its acceptor stem still bound to EF-Tu.

The antibiotic _____________ is thought to inhibit translocation by blocking pivoting of the ribosomal head region.

X-ray crystallography studies have shown that tRNAs interact with the 30S ribosomal subunit through their _________ and with the 50S ribosomal subunit through their __________.

Spectinomycin and paromomycin are antibiotics that were used to help determine the ___________ and ___________ functions of the 30S ribosomal subunit.

The crystal structure of the Thermus thermophilis ribosome revealed that the twelve contacts between the subunits are mostly mediated by ribosomal proteins.

There are two classes of aminoacyl-tRNA synthetases,each approaches the tRNA molecule from the same side.

The crystal structure of IF1 bound to the 30S ribosomal subunit shows that IF1 binds to the _____________ of the ribosome.

The exit tunnel walls of the 50S ribosomal subunit are made of _______,which probably helps the hydrophobic side chains of the nascent polypeptide to slide through easily.

Match the major regions found on a tRNA molecule with their correct description. -This portion of tRNA base pairs with mRNA.E

tRNAs contain a number of modified bases that have been shown to be necessary for tRNA function.