Question 1

Oral manifestations of nevoid basal cell carcinoma syndrome consist of multiple cysts of the jaws that are

Accepted Answer

A)  central giant cell granulomas. 
B)  peripheral giant cell granulomas. 
C)  odontogenic keratocysts. 
D)  calcifying epithelial odontogenic tumors.

Question 2

Multiple mucosal neuroma syndrome includes multiple mucosal neuromas, medullary carcinoma of the thyroid gland, and

Accepted Answer

A)  telangiectases. 
B)  pheochromocytoma. 
C)  gastrointestinal polyposis. 
D)  blue sclera.

Question 3

Self-replication, or the ability to duplicate itself, is achievable by

Accepted Answer

A)  DNA. 
B)  amino acids. 
C)  meiosis. 
D)  genetic heterogeneity.

Question 4

Early diagnosis of pheochromocytoma is imperative because of the high malignant potential of

Accepted Answer

A)  squamous cell carcinoma. 
B)  basal cell carcinoma. 
C)  thyroid carcinoma. 
D)  osteogenic sarcoma.

Question 5

The majority of patients with Turner syndrome have a _____ phenotype and _____ chromosomes.

Accepted Answer

A)  male; 47 
B)  female; 46 
C)  female; 45 
D)  male; 44

Question 6

After metaphase of the first meiotic division

Accepted Answer

A)  the chromosomes split at the centromere and separate from one another. 
B)  the chromosomes do not split at the centromere but separate from one another. 
C)  each member of the pair migrates to one of the new cells, each of which contains 46 chromosomes but twice the final amount of DNA. 
D)  each member of the pair migrates to one of the new cells, each of which contains 23 chromosomes but half the final amount of DNA.

Question 7

A karyotype containing XXXY indicates _____ syndrome.

Accepted Answer

A)  Down 
B)  Klinefelter 
C)  Turner 
D)  cri du chat

Question 8

A patient with Ellis-van Creveld syndrome will

Accepted Answer

A)  show polydactyly on the radial side of the forearm. 
B)  be a little person. 
C)  lack an anterior maxillary vestibular sulcus. 
D)  lack a posterior mandibular sulcus.

Question 9

Cases of facial clefting occur in about 1 in _____ births.

Accepted Answer

A)  80 
B)  200 
C)  800 
D)  2000

Question 10

For each clinical syndrome below, select the corresponding chromosomal abnormality from the list provided.
-Turner

Accepted Answer

A) Characterized by multiple abnormalities in various organs 
B) Down syndrome as a result of nondisjunction 
C) Nondisjunction of the X chromosome in the paternal gamete 
D) Deletion on the short arm of chromosome 5 
E) Fertilized ovum has two X chromosomes plus a Y chromosome

Question 11

The primary dentition of a patient with coronal dentin dysplasia will appear

Accepted Answer

A)  normal. 
B)  opaque with an amber color. 
C)  translucent with an amber color. 
D)  translucent with a blue color.

Question 12

_________ is a consistent feature of mandibulofacial dysostosis.

Accepted Answer

A)  Hypertrichosis 
B)  Deafness 
C)  Hypertelorism 
D)  Kyphoscoliosis

Question 13

A man's X chromosome is transmitted to _____ of his daughters and _____ of his sons.

Accepted Answer

A)  none; none 
B)  none; all 
C)  all; none 
D)  all; all

Question 14

Genetic risk is a mathematical estimate of probability governed by chance. A condition having autosomal-dominant inheritance is transmitted vertically from one generation to the next with males affected more than females.

Accepted Answer

A)  Both statements are true. 
B)  Both statements are false. 
C)  The first statement is true; the second is false. 
D)  The first statement is false; the second is true.

Question 15

Genetic heterogeneity can cause amelogenesis imperfecta because of its inheritance pattern (X-linked, autosomal recessive, or autosomal dominant).

Accepted Answer

A)  Both the statement and reason are correct and related. 
B)  Both the statement and reason are correct but not related. 
C)  The statement is correct, but the reason is not. 
D)  The statement is not correct, but the reason is correct. 
E)  Neither the statement nor the reason is correct.

Question 16

The constriction present in all chromosomes that joins the short and long arms is termed

Accepted Answer

A)  trisomy. 
B)  nondisjunction. 
C)  centromere. 
D)  translocation.

Question 17

Telangiectasias of the oral mucosa for a patient with hereditary hemorrhagic telangiectasia will be especially prominent in which location?

Accepted Answer

A)  Tip and anterior dorsum of the tongue 
B)  Palate 
C)  Gingiva 
D)  Buccal mucosa

Question 18

__________ is an inherited disorder affecting the gingiva and periodontium, which is characterized by hyperkeratosis of the palms of the hands and soles of the feet.

Accepted Answer

A)  Cyclic neutropenia 
B)  Papillon-Lefèvre syndrome 
C)  Gingival fibromatosis 
D)  Laband syndrome

Question 19

Identify the term that describes a mating or marriage between close relatives:

Accepted Answer

A)  Chiasmata 
B)  Consanguinity 
C)  Trisomy 
D)  Translocation

Question 20

MATCHING
For each genetic definition below, select the corresponding genetic term from the list provided.
-Nonsex chromosomes that are identical for men and women

Accepted Answer

A) Autosomes 
B) Gamete 
C) Locus 
D) Mutation 
E) Phenotype
F)Syndrome

Exam 6: Genetics