Which Statement Describes the Missing Piece of Evidence That Would

Which statement describes the missing piece of evidence that would confirm that folic acid reduces the risk of cardiovascular disease?

A) Observational studies that show a direct relationship between the levels of homocysteine in the blood and the risk of cardiovascular disease.
B) Observational studies that show an inverse relationship between folic acid and the risk of cardiovascular disease.
C) Intervention trials that show that folic acid supplementation reduces the levels of homocysteine in the blood.
D) Intervention trials that show that folic acid supplementation reduces the risk of cardiovascular disease.

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