Question 1

Choose the correct answer from the list below. Not all of the answers will be used.
-The thermodynamic driving force of ATP synthesis caused by the pumping of protons is _______________.

Accepted Answer

A)  Peter Mitchell
B)  chemiosmotic theory
C)  binding-change
D)  loose
E)  ATPF) entropyG) alpha subunitH) tightI) glycerol 3-phosphateJ) c ringK) ATP-ADP translocaseL) malate-aspartate shuttleM) Sir Hans Krebs F

Question 2

The membrane protein __________________ couples the entry of ADP into the mitochondrial matrix with the exit of ATP.

Accepted Answer

ADP-ATP translocase

Question 3

What is the reaction of ATP synthase?

Accepted Answer

A)   AMP3- + 2 HPO42- + H+ ↔ ATP4- + H2O
B)   ADP3- + HPO42- + H+ ↔ ATP4- + H2O
C)   ADP3- + HPO42- + 2H+ ↔ ATP4- + H2O
D)   AMP3- + 2 HPO42- + 2H+ ↔ ATP4- + H2O
E)   None of the above B

Question 4

Provide a brief description of oxidative phosphorylation.

Accepted Answer

The answer of Provide a brief description of oxidative phosphorylation....

Question 5

Choose the correct answer from the list below. Not all of the answers will be used.
-Atractyloside inhibits the mitochondrial protein _______________.

Accepted Answer

A)  Peter Mitchell
B)  chemiosmotic theory
C)  binding-change
D)  loose
E)  ATPF) entropyG) alpha subunitH) tightI) glycerol 3-phosphateJ) c ringK) ATP-ADP translocaseL) malate-aspartate shuttleM) Sir Hans Krebs

Question 6

How does the rotation of the c ring lead to ATP synthesis?

Accepted Answer

A)   The c ring is linked tightly to the gamma and epsilon subunits in the stalk of F1.
B)   The c ring interacts with the beta subunit.
C)   The gamma subunit rotates with proton gradient formation, inducing the binding-change mechanism.
D)   All of the above.
E)   None of the above.

Question 7

Explain why carbon monoxide is toxic.

Accepted Answer

The answer of Explain why carbon monoxide is toxic....

Question 8

In the glycerol phosphate shuttle, cytoplasmic glycerol phosphate dehydrogenase uses cytoplasmic NADH to reduce __________________ to glycerol 3-phosphate.

Accepted Answer

The answer of In the glycerol phosphate shuttle, cytoplasmic glycerol...

Question 9

Choose the correct answer from the list below. Not all of the answers will be used.
-_______________ is the name given to the hypothesis proposed by Peter Mitchell to explain how ATP synthesis is coupled to electron transport.

Accepted Answer

A)  Peter Mitchell
B)  chemiosmotic theory
C)  binding-change
D)  loose
E)  ATPF) entropyG) alpha subunitH) tightI) glycerol 3-phosphateJ) c ringK) ATP-ADP translocaseL) malate-aspartate shuttleM) Sir Hans Krebs

Question 10

How is oxidative phosphorylation regulated?

Accepted Answer

The answer of How is oxidative phosphorylation regulated?...

Question 11

The protein that generates heat by permitting the influx of protons into the mitochondria without the synthesis of ATP is the __________________.

Accepted Answer

The answer of The protein that generates heat by permitting...

Question 12

Electron flow down the electron-transport chain leads to:

Accepted Answer

A)   the transport of protons across the inner mitochondrial membrane from inside the matrix to the intermembrane space.
B)   the transport of protons across the inner mitochondrial membrane from the intermembrane space into the matrix.
C)   the coupled synthesis of GTP.
D)   a dangerous imbalance of K+ ions across the mitochondrial membrane.
E)   None of the above.

Question 13

What are uncouplers? Provide an example of when they might be useful.

Accepted Answer

The answer of What are uncouplers? Provide an example of...

Question 14

When glucose is totally oxidized to CO2 and H2O, how many ATP molecules are made by oxidative phosphorylation out of a maximum yield of how many ATP molecules?

Accepted Answer

A)   12 out of 30
B)   26 out of 30
C)   26 out of 32
D)   12 out of 38
E)   None of the above.

Question 15

How does the glycerol 3-phosphate shuttle function?

Accepted Answer

The answer of How does the glycerol 3-phosphate shuttle function?...

Question 16

Choose the correct answer from the list below. Not all of the answers will be used.
-ADP transport into the mitochondria is coupled to the export of _______________.

Accepted Answer

A)  Peter Mitchell
B)  chemiosmotic theory
C)  binding-change
D)  loose
E)  ATPF) entropyG) alpha subunitH) tightI) glycerol 3-phosphateJ) c ringK) ATP-ADP translocaseL) malate-aspartate shuttleM) Sir Hans Krebs

Question 17

In the malate-aspartate shuttle, how is oxaloacetate (OAA) regenerated, given that there is no transporter for oxaloacetate across the inner membrane?

Accepted Answer

The answer of In the malate-aspartate shuttle, how is oxaloacetate...

Question 18

Choose the correct answer from the list below. Not all of the answers will be used.
-Dihydroxyacetone phosphate is part of the _______________ shuttle.

Accepted Answer

A)  Peter Mitchell
B)  chemiosmotic theory
C)  binding-change
D)  loose
E)  ATPF) entropyG) alpha subunitH) tightI) glycerol 3-phosphateJ) c ringK) ATP-ADP translocaseL) malate-aspartate shuttleM) Sir Hans Krebs

Question 19

Choose the correct answer from the list below. Not all of the answers will be used.
-Which form of the ATPase subunits is responsible for phosphorylation of ADP?

Accepted Answer

A)  Peter Mitchell
B)  chemiosmotic theory
C)  binding-change
D)  loose
E)  ATPF) entropyG) alpha subunitH) tightI) glycerol 3-phosphateJ) c ringK) ATP-ADP translocaseL) malate-aspartate shuttleM) Sir Hans Krebs

Question 20

What is the mechanism for nonshivering thermogenesis?

Accepted Answer

The answer of What is the mechanism for nonshivering thermogenesis?...

Exam 21: The Proton-Motive Force

Choose the correct answer from the list below. Not all of the answers will be used. -The thermodynamic driving force of ATP synthesis caused by the pumping of protons is _______________.

The membrane protein __________________ couples the entry of ADP into the mitochondrial matrix with the exit of ATP.

What is the reaction of ATP synthase?

Provide a brief description of oxidative phosphorylation.

Choose the correct answer from the list below. Not all of the answers will be used. -Atractyloside inhibits the mitochondrial protein _______________.

How does the rotation of the c ring lead to ATP synthesis?

Explain why carbon monoxide is toxic.

In the glycerol phosphate shuttle, cytoplasmic glycerol phosphate dehydrogenase uses cytoplasmic NADH to reduce __________________ to glycerol 3-phosphate.

Choose the correct answer from the list below. Not all of the answers will be used. -_______________ is the name given to the hypothesis proposed by Peter Mitchell to explain how ATP synthesis is coupled to electron transport.

How is oxidative phosphorylation regulated?

The protein that generates heat by permitting the influx of protons into the mitochondria without the synthesis of ATP is the __________________.

Electron flow down the electron-transport chain leads to:

What are uncouplers? Provide an example of when they might be useful.

When glucose is totally oxidized to CO₂ and H₂O, how many ATP molecules are made by oxidative phosphorylation out of a maximum yield of how many ATP molecules?

How does the glycerol 3-phosphate shuttle function?

Choose the correct answer from the list below. Not all of the answers will be used. -ADP transport into the mitochondria is coupled to the export of _______________.

In the malate-aspartate shuttle, how is oxaloacetate (OAA) regenerated, given that there is no transporter for oxaloacetate across the inner membrane?

Choose the correct answer from the list below. Not all of the answers will be used. -Dihydroxyacetone phosphate is part of the _______________ shuttle.

Choose the correct answer from the list below. Not all of the answers will be used. -Which form of the ATPase subunits is responsible for phosphorylation of ADP?

What is the mechanism for nonshivering thermogenesis?