IL-10-Deficient Mice Develop Spontaneous Colitis, a Disease Due to Chronic

IL-10-deficient mice develop spontaneous colitis, a disease due to chronic inflammation in the gastrointestinal (GI) tract. However, when these mice are housed in germ-free conditions, in which they lack all commensal microbes in their GI tract, no colitis was observed. In addition, one would expect germ-free IL-10-deficient mice to also show:

A) Evidence of enhanced systemic immune activation compared to conventionally housed il10^-/- mice
B) Enlarged mesenteric lymph nodes compared to conventionally housed il10^-/- mice
C) Elevated numbers of FoxP3+ T cells in the lamina propria compared to conventionally housed il10^-/- mice
D) Increased production of IgG antibodies compared to conventionally housed il10^-/- mice
E) Reduced production of IgA antibodies compared to conventionally housed il10^-/- mice

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