Question 1

Matching 
Choose the correct answer from the list. Not all the answers will be used.
-The enzyme _____ participates in a regulatory substrate cycle along with phosphofructokinase.

Accepted Answer

A)  fructose-1,6-bisphosphatase
B)  pentose phosphate
C)  pyruvate decarboxylase
D)  hypoglycemia
E)  phosphofructokinaseF) NADP+G) thiamine pyrophosphateH) ATPI) galactosemiaJ) NAD+K) fluoride ionL) pyruvateM) glucogenicN) FAD A

Question 2

Which enzyme is involved in substrate level phosphorylation in glycolysis?

Accepted Answer

A)  Hexokinase
B)  Pyruvate kinase
C)  Glyceraldehyde-3phosphate dehydrogenase
D)  Aldolase
E)  None of the above. B

Question 3

Which of the following enzymes catalyzes the transfer of a phosphoryl group from ATP to glucose?

Accepted Answer

A)  hexokinase
B)  phosphoglucose isomerase
C)  glucose-6-phosphatase
D)  phosphoglucose mutase
E)  A transfer such as this does not occur in glycolysis. A

Question 4

Which of the following reactions does not occur in mammals?

Accepted Answer

A)  pyruvate + NADH → lactate + NAD+
B)  ribulose-5-phosphoate → ribose-5-phosphate
C)  mannose + ATP → mannose-6-phosphate + ADP + Pi
D)  6-phophogluconate + NADP+ → ribulose-5-phosphate + NADPH + CO2
E)  pyruvate + NADH + H+ → CO2 + ethanol + NAD+

Question 5

Select the enzyme from the list which would catalyze the reaction shown below.

Accepted Answer

A)  hexokinase (HK) 
B)  pyruvate kinease (PK) 
C)  enolase
D)  phosphoglucomutase (PGM) 
E)  G3P dehydrogenase (G3PDH)

Question 6

Glucose is converted to ______ in skeletal muscle under anaerobic conditions.

Accepted Answer

A)  lactate
B)  acetyaldehyde
C)  fructose
D)  glycogen
E)  acetyl-CoA

Question 7

Aerobic glycolysis produces a net yield of ______ ATP.

Accepted Answer

A)  1
B)  2
C)  3
D)  4
E)  more than 4

Question 8

During glycolysis, the steps between glucose and formation of the triose phosphates collectively

Accepted Answer

A)  consume two ATP and two NADH molecules.
B)  consume two ATP molecules.
C)  produce two ADP and two NADH molecules.
D)  produce two ATP and two NAD+ molecules.
E)  consume two NAD+ molecules.

Question 9

Matching 
Choose the correct answer from the list. Not all the answers will be used.
-The products of glycolysis include: ATP, NADH, and ______.

Accepted Answer

A)  fructose-1,6-bisphosphatase
B)  pentose phosphate
C)  pyruvate decarboxylase
D)  hypoglycemia
E)  phosphofructokinaseF) NADP+G) thiamine pyrophosphateH) ATPI) galactosemiaJ) NAD+K) fluoride ionL) pyruvateM) glucogenicN) FAD

Question 10

Methanol is highly toxic, not because of its own activity, but because it is converted metabolically into formaldehyde, which is the actual poison.What enzyme catalyzes this conversion?

Accepted Answer

A)  methanol caboxylase
B)  methanol transferase
C)  alcohol transmutase
D)  alcohol carboxylase
E)  alcohol dehydrogenase

Question 11

Matching 
Choose the correct answer from the list. Not all the answers will be used.
-Vitamin B1 is a component of the coenzyme ______ essential for development of an electron sink necessary for decarboxylation of pyruvate.

Accepted Answer

A)  fructose-1,6-bisphosphatase
B)  pentose phosphate
C)  pyruvate decarboxylase
D)  hypoglycemia
E)  phosphofructokinaseF) NADP+G) thiamine pyrophosphateH) ATPI) galactosemiaJ) NAD+K) fluoride ionL) pyruvateM) glucogenicN) FAD

Question 12

Consider the following portion of the glycolytic sequence catalyzed by the enzymes above the arrows.Which products(s)will produce ATP?

Accepted Answer

A)  I, IV
B)  II, IV
C)  II only
D)  III, IV
E)  IV only

Question 13

ATP

Accepted Answer

A)  inhibits activity of phosphofructokinase (PFK) allosterically.
B)  activates activity of phosphofructokinase (PFK) allosterically.
C)  inhibits activity of phosphofructokinase (PFK) hormonally.
D)  activates activity of phosphofructokinase (PFK) hormonally.
E)  does not alter phosphofructokinase (PFK) activity.

Question 14

In which of the following metabolic conversions is ATP required during glycolysis?
I.  fructose-6-phosphate →  fructose-1,6-bisphosphate  
II.  glucose  → glucose-6-phosphate
III.  fructose-1,6-bisphosphate → dihydroxyacetone phosphate  +  glyceraldehyde-3-phosphate
IV.  glucose-6-phosphate  →  fructose-6-phosphate

Accepted Answer

A)  I only
B)  II only
C)  I, II
D)  I, III
E)  I, IV

Question 15

The enzymes that catalyze glycolysis are located in the

Accepted Answer

A)  endoplasmic reticulum.
B)  mitochondrial matrix.
C)  cytosol.
D)  inner mitochondrial membrane.
E)  outer mitochondrial membrane.

Question 16

Which enzyme has an intermediate of the form presented below?

Accepted Answer

A)  phosphofructokinase
B)  aldolase
C)  pyruvate decarboxylase
D)  glyceraldehyde-3-phosphate dehydrogenase
E)  triose phosphate isomerase

Question 17

Individuals with galactosemia

Accepted Answer

A)  cannot catabolize galactose via glycolysis.
B)  lack the enzyme hexokinase which is required for phosphorylation of galactose.
C)  lack the enzyme galactokinase which is required for interconversion between glucose-1-phosphate and galactose-1-phosphate.
D)  cannot synthesize galactose from glucose.
E)  lack adequate uridine diphosphosphate.

Question 18

Matching 
Choose the correct answer from the list. Not all the answers will be used.
-Glycolysis forms ____ under either aerobic or anaerobic conditions.

Accepted Answer

A)  fructose-1,6-bisphosphatase
B)  pentose phosphate
C)  pyruvate decarboxylase
D)  hypoglycemia
E)  phosphofructokinaseF) NADP+G) thiamine pyrophosphateH) ATPI) galactosemiaJ) NAD+K) fluoride ionL) pyruvateM) glucogenicN) FAD

Question 19

The enzyme _____forms a Schiff base upon formation of the enzyme-substrate complex allowing aspartate mediated cleavage of the substrate.

Accepted Answer

A)  hexokinase
B)  phosphoglucose isomerase
C)  glucose-6-phosphatase
D)  phosphoglucose mutase
E)  aldolase

Question 20

The reaction catalyzed by the enzyme aldolase has a $\Delta$G˚' ≈ +23 kJ/mol.In muscle cells, the reaction proceeds in this same, forward direction.How can this occur?

Accepted Answer

A)  This  Δ\DeltaΔ G˚' means it is thermodynamically favored.
B)  The enzyme changes the ∆G of the reaction in cells to something favorable.
C)  The concentration of reactant(s) must be significantly greater than product(s) in cells.
D)  The concentration of product(s) must be significantly greater than reactant(s) in cells.
E)  none of the above

Exam 16: Glucose Catabolism

Matching Choose the correct answer from the list. Not all the answers will be used. -The enzyme _____ participates in a regulatory substrate cycle along with phosphofructokinase.

Which enzyme is involved in substrate level phosphorylation in glycolysis?

Which of the following enzymes catalyzes the transfer of a phosphoryl group from ATP to glucose?

Which of the following reactions does not occur in mammals?

Select the enzyme from the list which would catalyze the reaction shown below.

Glucose is converted to ______ in skeletal muscle under anaerobic conditions.

Aerobic glycolysis produces a net yield of ______ ATP.

During glycolysis, the steps between glucose and formation of the triose phosphates collectively

Matching Choose the correct answer from the list. Not all the answers will be used. -The products of glycolysis include: ATP, NADH, and ______.

Methanol is highly toxic, not because of its own activity, but because it is converted metabolically into formaldehyde, which is the actual poison.What enzyme catalyzes this conversion?

Matching Choose the correct answer from the list. Not all the answers will be used. -Vitamin B₁ is a component of the coenzyme ______ essential for development of an electron sink necessary for decarboxylation of pyruvate.

Consider the following portion of the glycolytic sequence catalyzed by the enzymes above the arrows.Which products(s) will produce ATP?

ATP

The enzymes that catalyze glycolysis are located in the

Which enzyme has an intermediate of the form presented below?

Individuals with galactosemia

Matching Choose the correct answer from the list. Not all the answers will be used. -Glycolysis forms ____ under either aerobic or anaerobic conditions.

The enzyme _____forms a Schiff base upon formation of the enzyme-substrate complex allowing aspartate mediated cleavage of the substrate.

The reaction catalyzed by the enzyme aldolase has a $\Delta$ G˚' ≈ +23 kJ/mol.In muscle cells, the reaction proceeds in this same, forward direction.How can this occur?

Exam 16: Glucose Catabolism

Matching Choose the correct answer from the list. Not all the answers will be used. -The enzyme _____ participates in a regulatory substrate cycle along with phosphofructokinase.

Which enzyme is involved in substrate level phosphorylation in glycolysis?

Which of the following enzymes catalyzes the transfer of a phosphoryl group from ATP to glucose?

Which of the following reactions does not occur in mammals?

Select the enzyme from the list which would catalyze the reaction shown below.

Glucose is converted to ______ in skeletal muscle under anaerobic conditions.

Aerobic glycolysis produces a net yield of ______ ATP.

During glycolysis, the steps between glucose and formation of the triose phosphates collectively

Matching Choose the correct answer from the list. Not all the answers will be used. -The products of glycolysis include: ATP, NADH, and ______.

Methanol is highly toxic, not because of its own activity, but because it is converted metabolically into formaldehyde, which is the actual poison.What enzyme catalyzes this conversion?

Matching Choose the correct answer from the list. Not all the answers will be used. -Vitamin B1 is a component of the coenzyme ______ essential for development of an electron sink necessary for decarboxylation of pyruvate.

Consider the following portion of the glycolytic sequence catalyzed by the enzymes above the arrows.Which products(s) will produce ATP?

ATP

The enzymes that catalyze glycolysis are located in the

Which enzyme has an intermediate of the form presented below?

Individuals with galactosemia

Matching Choose the correct answer from the list. Not all the answers will be used. -Glycolysis forms ____ under either aerobic or anaerobic conditions.

The enzyme _____forms a Schiff base upon formation of the enzyme-substrate complex allowing aspartate mediated cleavage of the substrate.

The reaction catalyzed by the enzyme aldolase has a Δ\DeltaΔ G˚' ≈ +23 kJ/mol.In muscle cells, the reaction proceeds in this same, forward direction.How can this occur?

Matching Choose the correct answer from the list. Not all the answers will be used. -Vitamin B₁ is a component of the coenzyme ______ essential for development of an electron sink necessary for decarboxylation of pyruvate.

The reaction catalyzed by the enzyme aldolase has a $\Delta$ G˚' ≈ +23 kJ/mol.In muscle cells, the reaction proceeds in this same, forward direction.How can this occur?