Question 1

The fluorescent antinuclear antibody test for lupus is an example of which of the following?

Accepted Answer

A)  Competitive immunoassay 
B)  Immunofixation 
C)  Indirect fluorescence testing 
D)  Direct fluorescence testing

Question 2

Antibodies directed against thyroglobulin represent a significant finding in which of the following autoimmune diseases?

Accepted Answer

A)  Myasthenia gravis 
B)  Multiple sclerosis 
C)  Hashimoto's thyroiditis 
D)  Contact dermatitis

Question 3

A 40-year-old female patient has increased thyroid-stimulating hormone (TSH)and decreased T4 levels with a normal T3 level.Antithyroglobulin is measured as 1:1280,and the antimicrosomal level is reportedly 1:6400.This patient most likely has:

Accepted Answer

A)  type 1 diabetes. 
B)  Graves disease. 
C)  Hashimoto's thyroiditis. 
D)  systemic lupus erythematosus.

Question 4

A 25-year-old female sees her physician because of swelling in the joints of her hands and generally feeling tired and rundown.A slide agglutination test for antibody directed against IgG is positive.What is the most likely cause of her symptoms?

Accepted Answer

A)  Autoimmune hemolytic anemia 
B)  Rheumatoid arthritis 
C)  Mononucleosis 
D)  Syphilis

Question 5

A 40-year-old woman presents with a lemon-yellow,waxy pallor and a red,beefy tongue.She is extremely fatigued and is having difficulty getting up in the morning and getting through the day.Antiparietal cell antibodies are found in her serum.This woman most likely has:

Accepted Answer

A)  Graves disease. 
B)  pernicious anemia. 
C)  ulcerative colitis. 
D)  type 1 diabetes.

Question 6

Antibodies to cyclic citrullinated proteins (anti-CCP)are specific diagnostic indicators for:

Accepted Answer

A)  type 1 diabetes mellitus. 
B)  celiac disease. 
C)  rheumatoid arthritis. 
D)  biliary cirrhosis.

Question 7

A 35-year-old female experiences difficulty in walking,and her hands and feet are numb from time to time.Suspecting a disease involving the central nervous system,her physician orders magnetic resonance imaging (MRI).The MRI reveals lesions on the myelin sheath.What is the most likely disease?

Accepted Answer

A)  Goodpasture's syndrome 
B)  Multiple myeloma 
C)  Graves disease 
D)  Multiple sclerosis

Question 8

Homogeneous staining of the nucleus in an antinuclear antibody test indicates:

Accepted Answer

A)  anti-RNA antibody. 
B)  antibody to DNA-histone complexes. 
C)  anticentromere antibody. 
D)  antibody to extractable nuclear antigens.

Question 9

In the rheumatoid factor test,what is being detected?

Accepted Answer

A)  antinuclear antibody 
B)  antithyroglobulin antibody 
C)  IgM directed against IgG 
D)  IgG directed against IgM

Question 10

Autoimmune hemolytic anemia targets which cells or tissues?

Accepted Answer

A)  Liver 
B)  Platelets 
C)  Red blood cells 
D)  Connective tissues

Question 11

A 30-year-old clinical laboratory science student complains of being tired but is not able to sleep.The woman also states that her hair has been breaking off,and she has lost 20 pounds over the past 2 months without trying.The woman's pulse and blood pressure are elevated,and her eyes seem to be bulging.Her complete blood count (CBC)is normal,thyroid-stimulating hormone is decreased,and T4 is increased.Antimicrosomal and antithyroglobulin antibodies are each 1:400.This woman most likely has:

Accepted Answer

A)  Addison's disease. 
B)  Graves disease. 
C)  Hashimoto's thyroiditis. 
D)  type 1 diabetes.

Question 12

A disease characterized by hypoactivity of the thyroid with weight gain and a sluggish metabolism as a result of destruction of thyroglobulin best describes:

Accepted Answer

A)  Graves disease. 
B)  Hashimoto's thyroiditis. 
C)  myasthenia gravis. 
D)  rheumatoid arthritis.

Question 13

An autoimmune disease characterized by pain and progressive destruction of the joints,weight loss,morning stiffness,and presence of an antibody directed against IgG best describes:

Accepted Answer

A)  rheumatoid arthritis. 
B)  lupus. 
C)  hemolytic disease of the newborn. 
D)  hemolytic anemia.

Question 14

Citrullinated proteins:

Accepted Answer

A)  are modified by carbohydrate side chains. 
B)  contain modified (atypical) amino acids. 
C)  are denatured nucleic acids. 
D)  are microbial toxins.

Question 15

A 45-year-old male presents to his physician complaining of achy joints,chronic runny nose,and coughing up blood.Chest x-ray shows pulmonary infiltrates.Cortisol is increased; erythrocyte sedimentation rate (ESR)is slightly elevated.Tests for autoantibodies are positive for antineutrophil cytoplasmic antibodies.On the basis of these findings,a likely diagnosis for this patient is:

Accepted Answer

A)  systemic lupus erythematosus. 
B)  rheumatoid arthritis. 
C)  chronic granulomatous disease. 
D)  Wegener's granulomatosis.

Exam 15: Autoimmunity