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Biology
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Genetic Analysis
Exam 22: Population Genetics and Evolution
Path 4
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Question 1
Short Answer
When looking at the MN blood group with three alleles,how many degrees of freedom will be used to compare observed versus expected results?
Question 2
Short Answer
Using the allele frequencies in the table below,what is the probability that a random person who was heterozygous 12/14 for VWA would also be homozygous 18/18 for FGA?
Question 3
Short Answer
What type of statistical analysis is used to compare observed and expected results in order to evaluate the validity of an estimate based on the Hardy-Weinberg equilibrium?
Question 4
Multiple Choice
Physical separation of a segment of a large population by a physical barrier that prevents gene flow can lead to
Question 5
Essay
What are the three key elements for determining F,a measure that a particular allele is IBD,using pedigree analysis?
Question 6
Short Answer
If the frequency of PKU (an autosomal recessive disease)is 1%,what percentage of the population are completely unaffected (homozygous dominant)?
Question 7
Multiple Choice
When populations share a single habitat but are isolated by genetic or postzygotic mechanisms that prevent gene flow,what process can cause populations to diverge?
Question 8
Essay
Explain why rare recessive alleles are more likely to produce a recessive phenotype as a result of inbreeding.
Question 9
Short Answer
Forward and reverse mutation can create a ________,given a sufficient number of generations and the absence of other evolutionary processes.
Question 10
Multiple Choice
Cheetahs exhibit significant inbreeding and loss of heterozygosity due to overhunting and loss of habitat experienced at some point in their evolutionary history.Which genetic mechanism occurs when a large population is substantially reduced at random,acting independently of natural selection?
Question 11
Essay
Achrondroplasia is an autosomal dominant genetic disorder,while red-green color blindness is an X-linked recessive disorder.For a given population,the frequency of achondroplasia is 1 in 25,000.If red-green color blindness affects 9% of males,what percentage of the population would you expect to be a. colorblind males of normal height? b. colorblind females of normal height? c. males with normal vision and achondroplasia? d. females with normal vision and achondroplasia? e. males with both colorblindness and achondroplasia? f. females with both colorblindness and achondroplasia?
Question 12
Essay
In the general population,1 in 300 individuals is a carrier for Tay-Sachs disease,while 1 in 30 individuals of Ashkenazi Jew descent are carriers.Tay-Sachs also affects 1 in 30 individuals with French-Canadian ancestry,although two completely unique mutations are responsible for the Ashkenazi and French-Canadian mutations. -What are the chances of two individuals who are carriers having a child with Tay-Sachs if a. both individuals are not of Ashkenazi or French-Canadian descent? b. one individual is of Ashkenazi descent and one is not? c. both individuals are of Ashkenazi descent?
Question 13
Multiple Choice
Given the following pedigree,what is the coefficient of inbreeding for individual V-1?
Question 14
Short Answer
Inbreeding depression,the reduction in fitness of inbred organisms,often results from the reduced level of what (within the gene pool)?
Question 15
Short Answer
The coefficient of inbreeding quantifies the probability that two alleles in a homozygous individual are ________,having descended from the same copy of the allele carried by a common ancestor of the inbred individual.