Question 1

A patient has a splitting headache shortly before getting her blood tested.She takes a couple of aspirin, and is scheduled for platelet aggregation studies.What effect will this have on the platelet aggregation studies?

Accepted Answer

A) Patient platelets will show diminished activity with selected agonists. 
B) Patient platelets will show normal activity with all agonists. 
C) Patient platelets will show increased activity with selected agonists. 
D) Patient platelets will show variable activity with all agonists.

Question 2

Thrombocytosis is associated with which of the following?

Accepted Answer

A) Acute leukemia 
B) ITP 
C) HUS 
D) Myeloproliferative disorder

Question 3

Immune complexes induce vasculitis by which of the following processes?

Accepted Answer

A) Inducing aggregation of platelets and activation factor XII 
B) Increasing pressure within the lumen of capillaries 
C) Formation of thrombi in the small vessels, inducing necrosis. 
D) Release of enzymes and free oxygen radicals from neutrophils which have migrated to the area to phagocytize the immune complexes

Question 4

A patient visits his physician because of unexplained bruising and prolonged bleeding from a recent tooth extraction.The physician orders a prothrombin time (PT) and an APTT.Results are within normal reference ranges.What other tests could the physician order to investigate his patient's symptoms?

Accepted Answer

A) Platelet count and platelet function assays 
B) Platelet function assays 
C) Platelet count only 
D) Repeat the PT and the APTT after the beginning of treatment.

Question 5

Splenomegaly can cause thrombocytopenia by which of the following mechanisms?

Accepted Answer

A) Impaired production 
B) Platelet sequestration 
C) Immune-mediated 
D) Mechanical destruction

Question 6

Which hemostatic disorder usually is represented by a decreased platelet count, normal PT, normal APTT, and abnormal bleeding time?

Accepted Answer

A) Thrombocytosis 
B) Thrombocytopenia 
C) Vascular disorders 
D) Platelet dysfunction

Question 7

A patient has a platelet count of 80 x 109/L and a bleeding time of 15 min.From what is the patient most likely suffering?

Accepted Answer

A) A platelet function disorder 
B) A quantitative platelet disorder 
C) A combined platelet disorder 
D) von Willebrand Disease

Question 8

What is the most common cause of thrombocytopenia?

Accepted Answer

A) Dilutional thrombocytopenia 
B) Increased destruction 
C) Decreased production 
D) Increased splenic sequestration

Question 9

Aspirin affects platelet aggregation because it interferes with:

Accepted Answer

A) Cyclooxygenase activity. 
B) Platelet adhesion to collagen. 
C) Development of platelets. 
D) Binding of fibrinogen to platelets.

Question 10

Scurvy can lead to vascular defects by which of the following mechanisms?

Accepted Answer

A) Degeneration of ECM 
B) Excessive breakdown of collagen 
C) Insufficient collagen synthesis 
D) Presence of paraproteins directed against collagen

Question 11

Which of the following is a mechanism of inducing thrombocytopenia in a patient?

Accepted Answer

A) Antibody-mediated platelet destruction 
B) Inherited platelet membrane defect 
C) Increased splenic sequestration 
D) All of the above

Question 12

Explain the pathophysiology of the following, and why each typically has normal coagulation screening tests.
A)Bernard-Soulier syndrome
B)Glanzmann's thrombasthenia
C)$\delta$-Storage pool disease
D)Gray platelet syndrome

Accepted Answer

The answer of Explain the pathophysiology of the following, and...

Question 13

Acquired disorders of the vascular system including senile purpura, Cushing's syndrome, corticosteroid therapy, and scurvy have one condition in common.Which of the following best describes this condition?

Accepted Answer

A) Decreased amount of supportive connective tissue in the blood vessel walls 
B) Presence of abnormal proteins in the vascular system 
C) Inflammation of the small blood vessels 
D) Increased pressure within the lumen of capillaries after intense exercise

Exam 30: Disorders of Primary Hemostasis

A patient has a splitting headache shortly before getting her blood tested.She takes a couple of aspirin, and is scheduled for platelet aggregation studies.What effect will this have on the platelet aggregation studies?

Thrombocytosis is associated with which of the following?

Immune complexes induce vasculitis by which of the following processes?

A patient visits his physician because of unexplained bruising and prolonged bleeding from a recent tooth extraction.The physician orders a prothrombin time (PT) and an APTT.Results are within normal reference ranges.What other tests could the physician order to investigate his patient's symptoms?

Splenomegaly can cause thrombocytopenia by which of the following mechanisms?

Which hemostatic disorder usually is represented by a decreased platelet count, normal PT, normal APTT, and abnormal bleeding time?

A patient has a platelet count of 80 x 109/L and a bleeding time of 15 min.From what is the patient most likely suffering?

What is the most common cause of thrombocytopenia?

Aspirin affects platelet aggregation because it interferes with:

Scurvy can lead to vascular defects by which of the following mechanisms?

Which of the following is a mechanism of inducing thrombocytopenia in a patient?

Explain the pathophysiology of the following, and why each typically has normal coagulation screening tests. A)Bernard-Soulier syndrome B)Glanzmann's thrombasthenia C) $\delta$ -Storage pool disease D)Gray platelet syndrome

Acquired disorders of the vascular system including senile purpura, Cushing's syndrome, corticosteroid therapy, and scurvy have one condition in common.Which of the following best describes this condition?

Exam 30: Disorders of Primary Hemostasis

A patient has a splitting headache shortly before getting her blood tested.She takes a couple of aspirin, and is scheduled for platelet aggregation studies.What effect will this have on the platelet aggregation studies?

Thrombocytosis is associated with which of the following?

Immune complexes induce vasculitis by which of the following processes?

A patient visits his physician because of unexplained bruising and prolonged bleeding from a recent tooth extraction.The physician orders a prothrombin time (PT) and an APTT.Results are within normal reference ranges.What other tests could the physician order to investigate his patient's symptoms?

Splenomegaly can cause thrombocytopenia by which of the following mechanisms?

Which hemostatic disorder usually is represented by a decreased platelet count, normal PT, normal APTT, and abnormal bleeding time?

A patient has a platelet count of 80 x 109/L and a bleeding time of 15 min.From what is the patient most likely suffering?

What is the most common cause of thrombocytopenia?

Aspirin affects platelet aggregation because it interferes with:

Scurvy can lead to vascular defects by which of the following mechanisms?

Which of the following is a mechanism of inducing thrombocytopenia in a patient?

Explain the pathophysiology of the following, and why each typically has normal coagulation screening tests. A)Bernard-Soulier syndrome B)Glanzmann's thrombasthenia C) δ\deltaδ -Storage pool disease D)Gray platelet syndrome

Acquired disorders of the vascular system including senile purpura, Cushing's syndrome, corticosteroid therapy, and scurvy have one condition in common.Which of the following best describes this condition?

Explain the pathophysiology of the following, and why each typically has normal coagulation screening tests. A)Bernard-Soulier syndrome B)Glanzmann's thrombasthenia C) $\delta$ -Storage pool disease D)Gray platelet syndrome