Traditional Therapy in APL Includes Pharmacological Concentration of RA (ATRA)

Traditional therapy in APL includes pharmacological concentration of RA (ATRA) and chemotherapy.What is the function of the chemotherapy component in this treatment protocol?

A) Induces maturation of the promyelocytes to mature granulocytes
B) Binds with the target PML/RAR gene, and represses gene transcription
C) Eradicates the leukemic stem cells
D) Induces cytolysis of the malignant promyelocytes

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