Question 1

The pathogenesis of some verrucous carcinomas is believed to be related to which of the following factors?

Accepted Answer

A)  Treponema pallidum
B)  Human papillomavirus subtypes 16 and 18
C)  Chronic ethanol ingestion
D)  Epstein-Barr virus
E)  Chronic irritation B

Question 2

Human papillomaviruses, subtypes 16 and 18, have been implicated in the etiology of which of the following?

Accepted Answer

A)  Burkitt's lymphoma
B)  Verrucous carcinoma
C)  Carcinoma of the nasopharynx
D)  Oral Kaposi's sarcoma
E)  Salivary gland adenocarcinomas B

Question 3

Oral squamous papillomas:

Accepted Answer

A)  Are composed of squamous epithelium supported by connective tissue
B)  Are rare lesions
C)  Are a component of the Peutz-Jeghers syndrome
D)  Have moderate malignant potential
E)  Are caused by cytomegalovirus (CMV)  A

Question 4

Which of the more than 100 human papillomavirus subtypes have been associated with the development of human carcinomas?

Accepted Answer

A)  Subtypes 2 and 6
B)  Subtypes 11 and 13
C)  Subtypes 16 and 18
D)  Subtypes 13 and 79a
E)  All the above

Question 5

The lesion that may spontaneously involute that mimics squamous cell carcinoma both clinically and microscopically is known as:

Accepted Answer

A)  Papilloma
B)  Keratoacanthoma
C)  Peripheral giant cell granuloma
D)  Condyloma acuminatum
E)  Verruca vulgaris

Question 6

Which of the following lesions is composed predominantly of benign epithelium?

Accepted Answer

A)  Denture-induced hyperplasia
B)  Squamous papilloma
C)  Granular cell tumor
D)  Mucosal neuroma
E)  None of the above

Question 7

All the following statements relative to oral verrucous carcinoma are correct except:

Accepted Answer

A)  May develop from proliferative verrucous leukoplakia
B)  Typically metastasizes early to submandibular lymph nodes
C)  Usually treated with surgery
D)  Microscopically well differentiated
E)  Is both exophytic and endophytic

Question 8

Human papillomavirus has been found in which of the following oral lesions?

Accepted Answer

A)  Verrucous carcinoma
B)  Proliferative verrucous leukoplakia
C)  Oral warts
D)  Squamous papillomas
E)  All the above

Question 9

Verrucous carcinoma can be a sequela of which of the following?

Accepted Answer

A)  Secondary syphilis
B)  Proliferative verrucous leukoplakia
C)  Neurofibromatosis
D)  Nevoid basal cell carcinoma syndrome
E)  Verruca vulgaris

Question 10

Which of the following verrucal-papillary lesions is associated with the wearing of ill-fitting dentures and frequently Candida albicans overgrowth?

Accepted Answer

A)  Papillary hyperplasia
B)  Verrucous carcinoma
C)  Keratoacanthoma
D)  Condyloma acuminatum
E)  Oral wart

Question 11

Significant risk of malignant transformation is associated with which of the following?

Accepted Answer

A)  Papillary hyperplasia
B)  Peripheral ossifying fibroma
C)  Squamous papilloma
D)  Focal epithelial hyperplasia (Heck's disease) 
E)  None of the above

Question 12

Oral verrucous carcinoma:

Accepted Answer

A)  Is usually treated with surgery
B)  May be related to the use of smokeless tobacco
C)  Is microscopically well differentiated
D)  Rarely metastasizes to the lung
E)  All the above

Question 13

A firm asymptomatic submucosal lump, measuring 1 ´ 1 cm, appeared in the posterior hard palate of a 27-year-old man. The duration of the lesion was believed to be approximately 1 month. Clinical differential diagnosis should include all of the following except:

Accepted Answer

A)  Lymphoma
B)  Mucocele
C)  Malignant salivary gland tumor
D)  Benign salivary gland tumor
E)  Squamous papilloma

Question 14

A 1 ´ 1 cm pedunculated lesion of the soft palate was described microscopically as being composed of projections of benign epithelium supported by small amounts of fibrovascular tissue. This describes which of the following?

Accepted Answer

A)  Mixed tumor of salivary gland
B)  Keratoacanthoma
C)  Squamous papilloma
D)  Focal fibrous hyperplasia
E)  Mucous extravasation phenomenon

Question 15

Which of the following verrucal-papillary lesions is associated with chronic candidiasis and the wearing of ill-fitting dentures?

Accepted Answer

A)  Verrucous carcinoma
B)  Verruca vulgaris (oral wart) 
C)  Dysplasia
D)  Keratoacanthoma
E)  None of the above

Exam 6: Verrucal-Papillary Lesions