Question 1

The most reliable and specific test for diagnosing DIC is:

Accepted Answer

A)  prothrombin time (PT) .
B)  activated partial thromboplastin time (aPTT) .
C)  fibrin degradation products (FDP) .
D)  D-dimer. D

Question 2

Match the causes or diagnostic tests with the hematologic disorders.
-Hodgkin disease

Accepted Answer

A)  Epstein-Barr virus
B)  Bence Jones protein
C)  Diagnosed by the Reed-Sternberg (RS)  cell
D)  Diagnosed by the Philadelphia chromosome C

Question 3

Philadelphia chromosome is present in lymph nodes of an individual with Hodgkin disease.

Accepted Answer

A) True 
 B)False  False

Question 4

In DIC, a large amount of microvascular and macrovascular occlusion may occur that is not clinically obvious.

Accepted Answer

A) True 
 B)False

Question 5

Match the causes or diagnostic tests with the hematologic disorders.
-Chronic myelogenous leukemia (CML)

Accepted Answer

A)  Epstein-Barr virus
B)  Bence Jones protein
C)  Diagnosed by the Reed-Sternberg (RS)  cell
D)  Diagnosed by the Philadelphia chromosome

Question 6

What change is seen in leukocytes during an allergic disorder (type I) often caused by asthma, hay fever, and drug reactions?

Accepted Answer

A)  Neutrophilia
B)  Basophilia
C)  Eosinophilia
D)  Monocytosis

Question 7

In Hodgkin disease and non-Hodgkin lymphoma (NHL), T cell function is severely decreased.

Accepted Answer

A) True 
 B)False

Question 8

Vitamin _____ is required for normal clotting factor synthesis by the _____.

Accepted Answer

A)  K; kidneys
B)  D; kidneys
C)  K; liver
D)  D; liver

Question 9

Frequently the initial sign of Hodgkin disease is a painless mass, lump, or swelling, most commonly on the neck.

Accepted Answer

A) True 
 B)False

Question 10

Match the descriptions with the platelet disorders.
-Essential (primary) thrombocythemia (ET)

Accepted Answer

A)  Thrombi composed of platelets with minimal fibrin and erythrocytes that occlude arterioles and capillaries
B)  Causes ischemic signs and symptoms in the central nervous system
C)  Caused by an alteration of multipotent stem cells, resulting in an excess production of platelets
D)  Antibody-coated platelets removed from circulation by mononuclear phagocytes in the spleen

Question 11

Which disorder is described as an unregulated release of thrombin with subsequent fibrin formation and accelerated fibrinolysis?

Accepted Answer

A)  DIC
B)  ITP
C)  Heparin-induced thrombocytopenia (HIT) 
D)  Essential thrombocythemia (ET)

Question 12

RS cells represent malignant transformation and proliferation of:

Accepted Answer

A)  IL-1, IL-2, IL-5, and IL-6.
B)  tumor necrosis factor-beta.
C)  B cells.
D)  T cells.

Question 13

Heparin-induced thrombocytopenia (HIT) is described as a(n):

Accepted Answer

A)  IgG immune-mediated adverse drug reaction that reduces circulating platelets.
B)  hematologic reaction to heparin in which the bone marrow is unable to produce sufficient platelets to meet the body's needs.
C)  IgE-mediated allergic drug reaction that reduces circulating platelets.
D)  cell-mediated drug reaction in which macrophages process the heparin and platelet complexes that are then destroyed by activated cytotoxic T cells.

Question 14

Match the causes or diagnostic tests with the hematologic disorders.
-Multiple myeloma

Accepted Answer

A)  Epstein-Barr virus
B)  Bence Jones protein
C)  Diagnosed by the Reed-Sternberg (RS)  cell
D)  Diagnosed by the Philadelphia chromosome

Question 15

The two major forms of leukemia, acute and chronic, are classified by a predominant cell type and the rate at which the affected person develops clinical symptoms.

Accepted Answer

A) True 
 B)False

Question 16

Match the descriptions with the platelet disorders.
-Thrombotic thrombocytopenic purpura (TTP)

Accepted Answer

A)  Thrombi composed of platelets with minimal fibrin and erythrocytes that occlude arterioles and capillaries
B)  Causes ischemic signs and symptoms in the central nervous system
C)  Caused by an alteration of multipotent stem cells, resulting in an excess production of platelets
D)  Antibody-coated platelets removed from circulation by mononuclear phagocytes in the spleen

Question 17

In the leukemias, a single progenitor cell undergoes malignant transformation.

Accepted Answer

A) True 
 B)False

Question 18

In DIC, what activates the coagulation cascade?

Accepted Answer

A)  Cytokines, such as platelet-activating factor (PAF) , and tumor necrosis factor- alpha (TNF-a) 
B)  Thromboxane A causing platelets to aggregate and consume clotting factors
C)  Tissue factor (TF)  located in the endothelial layer of blood vessels and subcutaneous tissue
D)  Endotoxins from gram-negative and gram-positive bacteria circulating within the bloodstream

Question 19

Match the causes or diagnostic tests with the hematologic disorders.
-Infectious mononucleosis

Accepted Answer

A)  Epstein-Barr virus
B)  Bence Jones protein
C)  Diagnosed by the Reed-Sternberg (RS)  cell
D)  Diagnosed by the Philadelphia chromosome

Question 20

Match the descriptions with the platelet disorders.
-Immune thrombocytopenic purpura (ITP)

Accepted Answer

A)  Thrombi composed of platelets with minimal fibrin and erythrocytes that occlude arterioles and capillaries
B)  Causes ischemic signs and symptoms in the central nervous system
C)  Caused by an alteration of multipotent stem cells, resulting in an excess production of platelets
D)  Antibody-coated platelets removed from circulation by mononuclear phagocytes in the spleen

Exam 27: Alterations of Leukocyte, Lymphoid, and Hemostatic Function

The most reliable and specific test for diagnosing DIC is:

Match the causes or diagnostic tests with the hematologic disorders. -Hodgkin disease

Philadelphia chromosome is present in lymph nodes of an individual with Hodgkin disease.

In DIC, a large amount of microvascular and macrovascular occlusion may occur that is not clinically obvious.

Match the causes or diagnostic tests with the hematologic disorders. -Chronic myelogenous leukemia (CML)

What change is seen in leukocytes during an allergic disorder (type I) often caused by asthma, hay fever, and drug reactions?

In Hodgkin disease and non-Hodgkin lymphoma (NHL), T cell function is severely decreased.

Vitamin _ is required for normal clotting factor synthesis by the _.

Frequently the initial sign of Hodgkin disease is a painless mass, lump, or swelling, most commonly on the neck.

Match the descriptions with the platelet disorders. -Essential (primary) thrombocythemia (ET)

Which disorder is described as an unregulated release of thrombin with subsequent fibrin formation and accelerated fibrinolysis?

RS cells represent malignant transformation and proliferation of:

Heparin-induced thrombocytopenia (HIT) is described as a(n) :

Match the causes or diagnostic tests with the hematologic disorders. -Multiple myeloma

The two major forms of leukemia, acute and chronic, are classified by a predominant cell type and the rate at which the affected person develops clinical symptoms.

Match the descriptions with the platelet disorders. -Thrombotic thrombocytopenic purpura (TTP)

In the leukemias, a single progenitor cell undergoes malignant transformation.

In DIC, what activates the coagulation cascade?

Match the causes or diagnostic tests with the hematologic disorders. -Infectious mononucleosis

Match the descriptions with the platelet disorders. -Immune thrombocytopenic purpura (ITP)