Question 1

A patient is prescribed an oral medication. It is crucial that its active ingredients not be released until the medicine reaches the small intestine. The problem is how to deliver an oral medication to this area without its activity being chemically destroyed or altered by stomach acids. In what form should this medication be delivered?

Accepted Answer

A)   Compressed tablet
B)   Controlled-release tablet
C)   Sublingual dose form
D)   Enteric-coated tablet
E)   None of the above D

Question 2

David works for a pharmaceutical company. His job includes supervising the process by which a certain group of drugs are compounded for initial delivery into the body. One might say that David is involved in:

Accepted Answer

A)   biopharmaceutics.
B)   drug vehicle production.
C)   dosage form production.
D)   b and c.
E)   all of the above. E

Question 3

When bilirubin is transformed from a lipid-soluble substance to a water-soluble substance that can be excreted in the bile, the process is referred to as:

Accepted Answer

A)   conjugation.
B)   oxidation.
C)   hydrolysis.
D)   reduction.
E)   degenerative enzyme function. A

Question 4

Jessica, a pharmaceutical manufacturer, is asked to give a lecture titled "The Transport of Drugs from Bloodstream to Site of Action." Her lecture is on:

Accepted Answer

A)   absorption.
B)   dissolution.
C)   distribution.
D)   passive diffusion.
E)   reduction.

Question 5

Rate and extent of drug absorption depend on:

Accepted Answer

A)   surface area at the site.
B)   blood flow.
C)   concentration of the drug.
D)   lipophilicity.
E)   all of the above.

Question 6

Drug molecules are eliminated from the body through:

Accepted Answer

A)   the kidneys.
B)   saliva.
C)   the respiratory system.
D)   a and c.
E)   all of the above.

Question 7

Drugs that are administered orally frequently travel first to the liver before entering the general circulation. This is referred to as:

Accepted Answer

A)   biotransformation.
B)   oxidation.
C)   first-pass metabolism.
D)   prolonged drug transformation.
E)   none of the above.

Question 8

A new medication is developed that consists of two immiscible liquids. One liquid appears as globules uniformly dispersed throughout the other liquid. What is most likely to be used to maintain globule stability?

Accepted Answer

A)   Heat upon administration
B)   Cold storage
C)   An emulsifying agent
D)   Mixing immediately before parenteral administration
E)   b, c, and d

Question 9

A weak acid crosses barriers best when it is:

Accepted Answer

A)   ionized.
B)   in an acid medium.
C)   in an alkaline medium.
D)   a and b.
E)   a and c.

Question 10

A patient is given a solution drug form that is observed to react in her system by moving from an area of higher concentration to an area of lower concentration. Which of the following is true?

Accepted Answer

A)   This drug is traversing cellular membranes by passive diffusion.
B)   Her medication is demonstrating the least common means by which drugs move through the body to the absorbing surface.
C)   This route of absorption depicts the property of active transport.
D)   Proteins are doing all the work of transporting this solution.
E)   c and d

Question 11

Barium is used as an oral gastrointestinal radiopaque agent because it:

Accepted Answer

A)   will not interact with the gastrointestinal environment.
B)   does not cross gastrointestinal membranes well.
C)   will not form an insoluble complex or precipitate in the gastrointestinal medium.
D)   a and b.
E)   all of the above.

Exam 3: Biopharmaceutics and Pharmacokinetics