Question 1

Which of the following drugs is a potassium channel opener?

Accepted Answer

A)  Nicorandil
B)  Hydralazine
C)  Glibenclamide
D)  Amiloride A

Question 2

The following is true of procainamide except:

Accepted Answer

A)  It generates an active metabolite in the body
B)  Its plasma half-life is longer than that of quinidine
C)  On long-term use, it can cause systemic lupus erythematosus like illness
D)  It is effective in many cases of ventricular extrasystoles, not responding to lignocaine B

Question 3

Rapid intravenous injection of clonidine causes rise in BP due to:

Accepted Answer

A)  Stimulation of vasomotor centre
B)  Release of noradrenaline from adrenergic nerve endings
C)  Agonistic action on vascular ?-agonists adrenergic receptors
D)  Cardiac stimulation C

Question 4

Hypothyroidism is a possible consequence of prolonged therapy with:

Accepted Answer

A)  Amiodarone
B)  Mexiletine
C)  Sotalol
D)  Procainamide

Question 5

The most significant feature of the antiarrhythmic action of is:

Accepted Answer

A)  Suppression of phase-4 depolarization in ventricular ectopic foci
B)  Prolongation of action potential duration
C)  Prolongation of effective refractory period
D)  Depression of membrane responsiveness

Question 6

Select the drug which is a potassium channel opener as well as nitric oxide donor:

Accepted Answer

A)  Diazoxide
B)  Sodium nitroprusside
C)  Minoxidil
D)  Nicorandil

Question 7

The characteristic feature(s) of dihydropyridine calcium channel blockers is/are:

Accepted Answer

A)  They have minimal negative inotropic action on the heart
B)  They have no effect on A-V conduction
C)  They do not affect the activation-inactivation kinetics of the calcium channels
D)  All of the above

Question 8

Given drug is

Accepted Answer

A)  Nifedipine
B)  Felodipine
C)  Verapamil
D)  Isosorbide mononitrate

Question 9

The cardiac response to verapamil and nifedipine in human subjects is:

Accepted Answer

A)  Verapamil causes tachycardia while nifedipine causes bradycardia
B)  Both cause bradycardia
C)  Verapamil causes bradycardia while nifedipine causes tachycardia
D)  Both cause tachycardia

Question 10

Glyceryl trinitrate is administered by the following routes except:

Accepted Answer

A)  Oral
B)  Sublingual
C)  Intramuscular
D)  Intravenous

Question 11

The short acting dihydropyridine preparations can aggravate myocardial ischaemia by invoking:

Accepted Answer

A)  Coronary vasospasm
B)  Thrombus formation
C)  Vagal activation
D)  Reflex sympathetic discharge to the heart

Question 12

Quinidine is now used primarily for:

Accepted Answer

A)  Conversion of atrial fibrillation to sinus rhythm
B)  Control of ventricular rate in atrial flutter
C)  Termination of ventricular tachycardia
D)  Prevention of recurrences of atrial fibrillation/ ventricular tachycardia

Question 13

Propranolol should not be prescribed for a patient of angina pectoris who is already receiving:

Accepted Answer

A)  Nifedipine
B)  Felodipine
C)  Verapamil
D)  Isosorbide mononitrate

Question 14

Though nitrates and calcium channel blockers are both vasodilators, they are used concurrently in angina pectoris, because:

Accepted Answer

A)  They antagonise each other's side effects
B)  Nitrates primarily reduce preload while calcium channel blockers primarily reduce after-load
C)  Nitrates increase coronary flow while calcium channel blockers reduce cardiac work
D)  Both 'B' and 'C' are correct

Question 15

Beneficial effect/effects of diuretics in CHF patients include the following:

Accepted Answer

A)  Symptomatic relief
B)  Regression of pathological changes
C)  Prolongation of life expectancy
D)  Both 'A' and 'C'

Question 16

Which of the following drugs is most likely to accentuate varient (Prinzmetal) angina?

Accepted Answer

A)  Propranolol
B)  Atenolol
C)  Verapamil
D)  Dipyridamole

Question 17

Glyceryl trinitrate is used in CHF for:

Accepted Answer

A)  Routine treatment of mild to moderate chronic heart failure
B)  Rapid symptom relief in acute left ventricular failure
C)  Arresting disease progression
D)  Both 'A' and 'B'

Question 18

The most likely mechanism of antihypertensive action of thiazide diuretics in the long-term is:

Accepted Answer

A)  Reduction of circulating blood volume
B)  Reduction in cardiac output
C)  Decreased sympathetic tone
D)  Reduction in total peripheral vascular resistance and improved compliance of resistance Vessels

Question 19

The dihydropyridines block the following type of calcium channels:

Accepted Answer

A)  L-type voltage sensitive channels
B)  T-type voltage sensitive channels
C)  N-type voltage sensitive channels
D)  Receptor operated calcium channels

Question 20

Vasodilators are used to treat:

Accepted Answer

A)  Acute heart failure attending myocardial infarction
B)  Chronic heart failure due to diastolic dysfunction
C)  Chronic heart failure due to both systolic as well as diastolic dysfunction
D)  All of the above

Exam 2: Cardiovascular Medications