In Proteins Being Made on Rough ER, Short Spans of Hydrophobic

In proteins being made on rough ER, short spans of hydrophobic amino acids that form $\alpha$ helices

A) induce a conformational change in the translocon, allowing them to exit into the ER membrane.
B) are posttranslationally inserted into the ER membrane by BiP.
C) are ubiquitinated and transferred into the cytosol for proteasomal degradation.
D) cause premature termination of translation, leading to the unfolded protein response.

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