Which Statement Describes Evidence That Supports the Signal Hypothesis as an Explanation

Which statement describes evidence that supports the signal hypothesis as an explanation for how secretory proteins are targeted to the rough ER?

A) The protein is larger when synthesized in vitro on free polysomes.
B) The secretory protein ends up in the cytosol when a short sequence is deleted by genetic engineering.
C) A normally cytosolic protein is secreted when a specific sequence is added to it by genetic engineering.
D) All of the above

Correct Answer:

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