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The Protein Encoded by the PTEN Gene Acts as a Tumor

Question 15

Multiple Choice

The protein encoded by the PTEN gene acts as a tumor suppressor by


A) phosphorylating p53 and increasing its proapoptotic activity.
B) antagonizing CDK4, 6/cyclin D activity to activate the G1 cell cycle restriction point.
C) dephosphorylating phosphatidylinositol 3,4,5-bisphosphate, thus antagonizing PI 3 kinase/Akt activity.
D) increasing expression of BRCA1 to protect cells against DNA damage.

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