Certain Patients Can Develop "Tolerance" to Opioid Analgesics,which Is Indicated

Certain patients can develop "tolerance" to opioid analgesics,which is indicated by

A) the onset of withdrawal symptoms if the drug is suddenly discontinued
B) the fact that the patient may still crave the drug several years after he/she has ceased taking it
C) the need to progressively increase the dosage of the drug to achieve a therapeutic effect when the drug is used for prolonged periods
D) all the above are true
E) none of the above are true

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