A 23-Year-Old Man Comes to the Physician Because of Intermittent

A 23-year-old man comes to the physician because of intermittent history of episodic shortness of breath. The patient has no history of recent illness.  He had eczema as a child.  The patient has no other medical conditions and takes no medications.  Vital signs are within normal limits. Physical examination reveals scattered expiratory wheezes in both lungs.  Peak expiratory flow rate is decreased from baseline.  Sputum microscopy reveals eosinophilic, hexagonal, double-pointed crystals.  The sputum findings in this patient are a direct result of which of the following cytokines?

A) IL-1
B) IL-5
C) IL-12
D) Interferon-gamma
E) TGF-B

Correct Answer:

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