A 18-Year-Old Male Is Examined Because He Has Had Lower

A 18-year-old male is examined because he has had lower extremities pain for three months. The discomfort is constant and is felt day and night. He has no history of leg trauma, a fever, or chills. The distal femur has an expansile lesion, as shown on imaging. Following a surgical resection, the specimen is displayed below. Mutations involving which of the following genes are most likely present in this patient?

A) BRAF
B) HER2
C) KRAS
D) RB1
E) RET

Correct Answer:

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