An 80-Year-Old Woman Is Assessed for Blisters on Both Feet

An 80-year-old woman is assessed for blisters on both feet that have formed in the last week. The patient is in a nursing home because of dementia, but he has no other chronic medical illnesses and is not on any medications. The vital indicators are within normal ranges. There are no lesions in the mouth. The display depicts the results of the examination. Which of the following is most likely involved in the pathogenesis of this patient's condition?

A) Deposition of IgA-containing immune complexes within dermal papillae
B) Deposition of IgG and complement at the dermal-epidermal junction
C) Deposition of IgG within the epidermal layer at the intercellular level
D) Disrupted assembly of keratin into monofilaments
E) Increased vascular permeability due to gaps between endothelial cells

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