A 76-Year-Old Man Has Been Experiencing Worsening Shortness of Breath

A 76-year-old man has been experiencing worsening shortness of breath, coughing, and weight loss for several months. He has never smoked in his life. Imaging of the chest reveals irregular pleural thickening. A surgical biopsy is planned, but the patient declines, preferring hospice care instead. He dies a few weeks later. An autopsy is performed, and a photograph of the cut lung section is displayed. Histopathological examination of the abnormal tissue is most likely to reveal which of the following findings?

A) Caseating granulomas with giant cells
B) Central areas of whorled collagen fibers
C) Small round cells positive for chromogranin
D) Spindle cells positive for cytokeratin
E) Thick, fibrinous exudate and pus

Correct Answer:

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