A 34-Year-Old Guy Arrives to the Clinic with a Lingering

A 34-year-old guy arrives to the clinic with a lingering skin rash. He has a 6-month history of a scaly rash on his upper and lower limbs, which is accompanied by moderate pruritus. The patient has tried topical antihistamines and emollients without success. Childhood asthma and orolabial herpes simplex virus infection stand out in the patient's medical history. He does not smoke or drink and works as a sales associate for a home improvement business. The patient was found to have skin lesions, as indicated in the photograph below. On histology, psoriasis is distinguished by hyperkeratosis and confluent parakeratosis of the stratum corneum (which results in the typical silvery scales visible on visual examination) , as well as widespread epidermal hyperplasia with elongated and clubbed rete ridges. This patient's disorder is most likely associated with which of the following extradermal complications?

A) Chronic glomerulonephritis
B) Deforming joint disease
C) Medullary thyroid cancer
D) Peripheral neuropathy
E) Pulmonary fibrosis

Correct Answer:

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