An 8-Year-Old Child Is Brought to the Clinic Because He

An 8-year-old child is brought to the clinic because he has had a lower extremities skin rash for three days. The rash started as sensitive papules and swiftly developed into vesicles and flaccid bullae that ruptured readily. The patient has no mucosal lesions or other rashes and has never before experienced such symptoms. He has had all necessary vaccines and does not taking any drugs. The results of the skin examination are displayed below. Which of the following is the most likely cause of this patient's skin findings?

A) Autoantibodies targeted against hemidesmosomes
B) Autoantibody-mediated epidermal cell separation
C) Bacterial toxin-induced desmoglein 1 cleavage
D) Defective epidermal barrier and T-cell dysregulation
E) Inflammatory response to viral lytic infection

Correct Answer:

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