Researchers Develop a Novel Agent to Treat Extrinsic Asthma

Researchers develop a novel agent to treat extrinsic asthma.  In a clinical trial, patients with moderate to severe asthma treated with this medication experience fewer exacerbations.  They are found to have lower levels of serum IgE, even after exposure to triggering allergens.  This medication helps improve asthma symptoms by binding and inhibiting the substance produced by sensitized Th2 cells in the airways that promotes immunoglobulin isotype switching in B lymphocytes.  Which of the following is the most likely target of this medication?

A) Interleukin-1
B) Interleukin-3
C) Interleukin-4
D) Interleukin-5
E) Interferon-gamma
F) Transforming growth factor-beta

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