A 2-Year-Old Boy Is Brought to the Office Due to Recurrent

A 2-year-old boy is brought to the office due to recurrent infections.  He was born at term after an uncomplicated pregnancy.  His mother states, "My boy is always sick with something and is constantly on antibiotics."  The patient has had multiple episodes of otitis media, skin infections, and pneumonia.  Incision and drainage of his skin infections revealed Staphylococcus aureus on bacterial culture but no purulence.  The infections usually resolve with prolonged antibiotic courses.  Laboratory testing reveals absent CD18 antigens on the surface of leukocytes.  This patient's underlying condition is most likely associated with which of the following?

A) Infection following live-virus vaccines
B) Infection with Neisseria
C) Persistent leukocytosis
D) Small or absent lymph nodes
E) Thrombocytopenia and eczema

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