A 55-Year-Old Man Is Evaluated Due to a Nonhealing Left

A 55-year-old man is evaluated due to a nonhealing left forearm wound.  The patient had an excisional biopsy of a suspicious skin lesion at the site of the wound several weeks ago.  He has a history of uncontrolled type 2 diabetes mellitus and hypertension.  Vital signs are within normal limits.  Physical examination shows a 2.5-cm wound surrounded by erythema on the left forearm.  Upregulation of which of the following would most likely improve fibroblast proliferation and reepithelization in this nonhealing wound?

A) Bradykinin release from endothelial cells
B) Cortisol release from the adrenal cortex
C) Glycation cross-links in collagen fibers
D) Production of IL-10 by macrophages
E) Release of reactive oxygen species from neutrophils

Correct Answer:

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