A 15-Year-Old Boy Develops Severe Cardiomyopathy Following Myocarditis from Coxsackie

A 15-year-old boy develops severe cardiomyopathy following myocarditis from Coxsackie virus and is placed on the cardiac transplant list.  Two weeks following his cardiac transplantation from a matched donor, he develops dyspnea on exertion.  Extensive evaluation is undertaken including cardiac catheterization and endomyocardial biopsy to assess for acute allograft rejection.  Which of the following histologic findings is most consistent with this diagnosis?

A) Concentric coronary artery intimal thickening
B) Dense interstitial lymphocytic infiltrate
C) Patchy necrosis with granulation tissue
D) Perivascular infiltrate with abundant eosinophils
E) Scant inflammatory cells and interstitial fibrosis

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