A 45-Year-Old Man Comes to Clinic for Routine Follow-Up

A 45-year-old man comes to clinic for routine follow-up.  He has a history of end-stage renal disease due to autosomal dominant polycystic kidney disease, and he underwent a deceased-donor kidney transplant 4 years ago.  The patient has hypertension that initially resolved following the transplant but redeveloped 6 months ago.  Review of his recent laboratory studies reveals a progressive increase in serum creatinine levels over the last few months.  Urinalysis is within normal limits.  On ultrasonography, the transplanted kidney is reduced in size.  A biopsy of the graft is most likely to show which of the following?

A) Dense mononuclear interstitial infiltration
B) Glomerular crescent formation
C) Obliterative vascular fibrosis
D) Tubular hypertrophy and intratubular casts
E) Vascular fibrinoid necrosis with thrombotic occlusion

Correct Answer:

Verified

Unlock this answer now
Get Access to more Verified Answers free of charge

Access For Free