A 6-Year-Old Girl with Chronic Anemia Requiring Repeated Blood Transfusions

A 6-year-old girl with chronic anemia requiring repeated blood transfusions is undergoing genetic testing.  The patient's mother and older sibling have a history of mild anemia.  Her peripheral blood smear shows hypochromic, microcytic red blood cells, and hemoglobin electrophoresis reveals a predominance of hemoglobins F and A2.  Sequencing of the Beta-globin gene is performed using the patient's erythroblast DNA.  A schematic representation of the gene and its transcribed RNA is shown in the image below. The base sequence indicated by the bold red arrow is responsible for which of the following functions?

A) Enhancement of transcription
B) Initiation of transcription
C) Initiation of translation
D) Repression of transcription
E) Termination of transcription

Correct Answer:

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