Solved

Passage the Drug Paracetamol, Also Known as Acetaminophen, Is Used to to Relieve

Question 139

Multiple Choice

Passage
The drug paracetamol, also known as acetaminophen, is used to relieve pain and fever, and is a metabolite of the antipyretic drug phenacetin (Figure 1) .  These two drugs have similar medicinal properties, but phenacetin has been shown to be carcinogenic and cause kidney damage.  Acetaminophen is a safer alternative to phenacetin when taken in therapeutic doses.
Passage The drug paracetamol, also known as acetaminophen, is used to relieve pain and fever, and is a metabolite of the antipyretic drug phenacetin (Figure 1) .  These two drugs have similar medicinal properties, but phenacetin has been shown to be carcinogenic and cause kidney damage.  Acetaminophen is a safer alternative to phenacetin when taken in therapeutic doses. <strong>Figure 1</strong>  Structure of phenacetinA student synthesizes acetaminophen in a laboratory from phenol according to the reactions shown.  The synthesis begins with the nitration of phenol by sodium nitrate (NaNO<sub>3</sub>) to produce the mixture of the isomers 2-nitrophenol and 4-nitrophenol (Reaction 1) .  These isomers can be easily separated by steam distillation to isolate the desired product, 4-nitrophenol.  Reduction of the nitro group with sodium borohydride (NaBH<sub>4</sub>) (Reaction 2) is followed by acetylation of the amine with acetic anhydride (Reaction 3) to afford the final product, acetaminophen. <strong>Reaction 1</strong> <strong>Reaction 2</strong> <strong>Reaction 3</strong> - Normal phase thin layer chromatography (TLC) was used to monitor the formation of acetaminophen.  According to the TLC plate shown, which spot has an R<sub>f</sub> value of 0.33, and what compound most likely corresponds to this spot? A) Spot A; acetaminophen B) Spot B; acetaminophen C) Spot A; 4-aminophenol D) Spot B; 4-aminophenol Figure 1  Structure of phenacetinA student synthesizes acetaminophen in a laboratory from phenol according to the reactions shown.  The synthesis begins with the nitration of phenol by sodium nitrate (NaNO3) to produce the mixture of the isomers 2-nitrophenol and 4-nitrophenol (Reaction 1) .  These isomers can be easily separated by steam distillation to isolate the desired product, 4-nitrophenol.  Reduction of the nitro group with sodium borohydride (NaBH4) (Reaction 2) is followed by acetylation of the amine with acetic anhydride (Reaction 3) to afford the final product, acetaminophen.
Passage The drug paracetamol, also known as acetaminophen, is used to relieve pain and fever, and is a metabolite of the antipyretic drug phenacetin (Figure 1) .  These two drugs have similar medicinal properties, but phenacetin has been shown to be carcinogenic and cause kidney damage.  Acetaminophen is a safer alternative to phenacetin when taken in therapeutic doses. <strong>Figure 1</strong>  Structure of phenacetinA student synthesizes acetaminophen in a laboratory from phenol according to the reactions shown.  The synthesis begins with the nitration of phenol by sodium nitrate (NaNO<sub>3</sub>) to produce the mixture of the isomers 2-nitrophenol and 4-nitrophenol (Reaction 1) .  These isomers can be easily separated by steam distillation to isolate the desired product, 4-nitrophenol.  Reduction of the nitro group with sodium borohydride (NaBH<sub>4</sub>) (Reaction 2) is followed by acetylation of the amine with acetic anhydride (Reaction 3) to afford the final product, acetaminophen. <strong>Reaction 1</strong> <strong>Reaction 2</strong> <strong>Reaction 3</strong> - Normal phase thin layer chromatography (TLC) was used to monitor the formation of acetaminophen.  According to the TLC plate shown, which spot has an R<sub>f</sub> value of 0.33, and what compound most likely corresponds to this spot? A) Spot A; acetaminophen B) Spot B; acetaminophen C) Spot A; 4-aminophenol D) Spot B; 4-aminophenol Reaction 1
Passage The drug paracetamol, also known as acetaminophen, is used to relieve pain and fever, and is a metabolite of the antipyretic drug phenacetin (Figure 1) .  These two drugs have similar medicinal properties, but phenacetin has been shown to be carcinogenic and cause kidney damage.  Acetaminophen is a safer alternative to phenacetin when taken in therapeutic doses. <strong>Figure 1</strong>  Structure of phenacetinA student synthesizes acetaminophen in a laboratory from phenol according to the reactions shown.  The synthesis begins with the nitration of phenol by sodium nitrate (NaNO<sub>3</sub>) to produce the mixture of the isomers 2-nitrophenol and 4-nitrophenol (Reaction 1) .  These isomers can be easily separated by steam distillation to isolate the desired product, 4-nitrophenol.  Reduction of the nitro group with sodium borohydride (NaBH<sub>4</sub>) (Reaction 2) is followed by acetylation of the amine with acetic anhydride (Reaction 3) to afford the final product, acetaminophen. <strong>Reaction 1</strong> <strong>Reaction 2</strong> <strong>Reaction 3</strong> - Normal phase thin layer chromatography (TLC) was used to monitor the formation of acetaminophen.  According to the TLC plate shown, which spot has an R<sub>f</sub> value of 0.33, and what compound most likely corresponds to this spot? A) Spot A; acetaminophen B) Spot B; acetaminophen C) Spot A; 4-aminophenol D) Spot B; 4-aminophenol Reaction 2
Passage The drug paracetamol, also known as acetaminophen, is used to relieve pain and fever, and is a metabolite of the antipyretic drug phenacetin (Figure 1) .  These two drugs have similar medicinal properties, but phenacetin has been shown to be carcinogenic and cause kidney damage.  Acetaminophen is a safer alternative to phenacetin when taken in therapeutic doses. <strong>Figure 1</strong>  Structure of phenacetinA student synthesizes acetaminophen in a laboratory from phenol according to the reactions shown.  The synthesis begins with the nitration of phenol by sodium nitrate (NaNO<sub>3</sub>) to produce the mixture of the isomers 2-nitrophenol and 4-nitrophenol (Reaction 1) .  These isomers can be easily separated by steam distillation to isolate the desired product, 4-nitrophenol.  Reduction of the nitro group with sodium borohydride (NaBH<sub>4</sub>) (Reaction 2) is followed by acetylation of the amine with acetic anhydride (Reaction 3) to afford the final product, acetaminophen. <strong>Reaction 1</strong> <strong>Reaction 2</strong> <strong>Reaction 3</strong> - Normal phase thin layer chromatography (TLC) was used to monitor the formation of acetaminophen.  According to the TLC plate shown, which spot has an R<sub>f</sub> value of 0.33, and what compound most likely corresponds to this spot? A) Spot A; acetaminophen B) Spot B; acetaminophen C) Spot A; 4-aminophenol D) Spot B; 4-aminophenol Reaction 3
-Passage The drug paracetamol, also known as acetaminophen, is used to relieve pain and fever, and is a metabolite of the antipyretic drug phenacetin (Figure 1) .  These two drugs have similar medicinal properties, but phenacetin has been shown to be carcinogenic and cause kidney damage.  Acetaminophen is a safer alternative to phenacetin when taken in therapeutic doses. <strong>Figure 1</strong>  Structure of phenacetinA student synthesizes acetaminophen in a laboratory from phenol according to the reactions shown.  The synthesis begins with the nitration of phenol by sodium nitrate (NaNO<sub>3</sub>) to produce the mixture of the isomers 2-nitrophenol and 4-nitrophenol (Reaction 1) .  These isomers can be easily separated by steam distillation to isolate the desired product, 4-nitrophenol.  Reduction of the nitro group with sodium borohydride (NaBH<sub>4</sub>) (Reaction 2) is followed by acetylation of the amine with acetic anhydride (Reaction 3) to afford the final product, acetaminophen. <strong>Reaction 1</strong> <strong>Reaction 2</strong> <strong>Reaction 3</strong> - Normal phase thin layer chromatography (TLC) was used to monitor the formation of acetaminophen.  According to the TLC plate shown, which spot has an R<sub>f</sub> value of 0.33, and what compound most likely corresponds to this spot? A) Spot A; acetaminophen B) Spot B; acetaminophen C) Spot A; 4-aminophenol D) Spot B; 4-aminophenol Normal phase thin layer chromatography (TLC) was used to monitor the formation of acetaminophen.  According to the TLC plate shown, which spot has an Rf value of 0.33, and what compound most likely corresponds to this spot?


A) Spot A; acetaminophen
B) Spot B; acetaminophen
C) Spot A; 4-aminophenol
D) Spot B; 4-aminophenol

Correct Answer:

verifed

Verified

Unlock this answer now
Get Access to more Verified Answers free of charge

Related Questions

Q134: Passage<br>Two key ingredients found in many soaps

Q135: Passage<br>Students used three classification tests to study

Q136: The infrared spectrum shows the frequencies of

Q137: What types of functional groups react to

Q138: Passage<br>Aldehydes are organic compounds encountered in everyday

Q140: Researchers want to synthesize valine from isovaleric

Q141: Passage<br>The β-lactam scaffold is an important feature

Q142: Passage<br>A group of students studied the reactivity

Q143: Passage<br>The β-lactam scaffold is an important feature

Q144: Passage<br>Students perform a synthesis of a carboxylic