A Three-Arm, Randomized Crossover Trial Is Conducted to Determine Whether

A three-arm, randomized crossover trial is conducted to determine whether the profile of circulating micro RNAs (miRNAs) is altered after acute resistance training with blood flow restriction (BFR) , as compared with unrestricted low- and high-volume training.  Eighteen healthy volunteers (mean age 25) are enrolled.  The arms are single bouts of leg flexion/extension resistance training at: 70% of the individual single-repetition maximum (1RM) 30% of the 1RM30% of the 1RM with BFR (artificially applied by a cuff at 300 mm Hg)
During each training intervention, load-associated outcomes (fatigue, heart rate, and exhaustion) are monitored.  Acute effects (circulating miRNAs and lactate) are determined using pre- and postintervention measurements.  Preliminary results show that lower lactate concentrations tend to correspond with lower miR-143-3p expression, and that the relationship is very strong and statistically significant.  Based on this information, which of the following statements is most correct about the correlation coefficient r for this relationship?

A) r is negative and probably closer to −1 than to 0
B) r is negative and probably closer to 0 than to −1
C) r is positive and probably closer to 0 than to 1
D) r is positive and probably closer to 1 than to 0

Correct Answer:

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