You Are Following Five Patients Who Have Had Various Aspects

You are following five patients who have had various aspects of their kidney function measured on one or more occasions over time.  All patients are clinically stable without any ongoing acute events.  Which of the following laboratory changes would represent the greatest loss in glomerular filtration rate?

A) Increase in serum creatinine from 0.8 to 1.2 mg/dL
B) Increase in serum creatinine from 4.0 to 8.0 mg/dL
C) Increase in BUN/creatinine ratio from 10 to 30
D) Increase in BUN from 10 to 20 mg/dL
E) Decrease in 24-hr urine creatinine clearance from 100 to 80 ml/min

Correct Answer:

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