A 1-Week-Old Newborn Is Seen for Abnormal Thyroid Function Tests

A 1-week-old newborn is seen for abnormal thyroid function tests that were performed as part of routine screening.  Serum thyroxine (T4) was low and serum TSH was normal.  The patient was born by spontaneous vaginal delivery at 40 weeks of gestation to a 28-year-old primigravida.  During the pregnancy, the mother took acetaminophen intermittently for low back pain.  Examination of the newborn shows no abnormal findings.  Repeat thyroid function test results are as follows: Which of the following is the most likely cause of the patient's abnormal thyroid function tests?

A) Decreased T4 to triiodothyronine conversion
B) Deficiency of thyroxine-binding globulin
C) Hypoalbuminemia
D) Hypopituitarism
E) Thyroid dysgenesis

Correct Answer:

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