A 44-Year-Old Man Comes to the Office Due to Increasing

A 44-year-old man comes to the office due to increasing shortness of breath.  While climbing the stairs to his second-floor apartment, the patient must now stop halfway to catch his breath.  He has a history of nonischemic cardiomyopathy and chronic heart failure with reduced ejection fraction.  After evaluation, treatment with a new medication is begun that improves his symptoms by increasing urine output and decreasing peripheral vascular resistance.  The medication works by inhibiting a metalloprotease to prolong the action of endogenous polypeptides.  These polypeptides are most likely secreted by which of the following cell types?

A) Adrenal zona glomerulosa cells
B) Cardiomyocytes
C) Hepatic stellate cells
D) Myocardial Purkinje fibers
E) Renal juxtaglomerular cells
F) Vascular endothelial cells

Correct Answer:

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