A 60-Year-Old Man with Known Coronary Artery Disease Comes to the Office

A 60-year-old man with known coronary artery disease comes to the office due to exertional chest tightness for the last 6 months.  The symptoms occur when he walks more than 3 blocks, especially in cold weather.  The patient underwent coronary artery bypass graft surgery 3 years ago for progressive angina.  Past medical history also includes asthma, benign prostate hyperplasia, and peripheral artery disease.  The physician discusses adding isosorbide dinitrate to his current therapy but the patient is concerned about adverse effects.  Which of the following is most likely to occur in this patient with the add-on therapy?

A) Atrioventricular conduction delay
B) Cold extremities
C) Constipation
D) Joint pains
E) Nocturnal wheezing
F) Throbbing headaches
G) Urinary retention

Correct Answer:

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