A Group of Investigators Is Studying Osteoprotegerin Function in Patients

A group of investigators is studying osteoprotegerin function in patients with postmenopausal osteoporosis.  Using an engineered mouse strain, they develop a chimeric monoclonal antibody that blocks binding of receptor activator of nuclear factor kappa B (RANK) to RANK ligand (RANK-L) .  The investigators inject this monoclonal antibody into human subjects.  Eight weeks later, a bone biopsy is obtained from all subjects.  Which of the following is the most likely observed finding?

A) Decreased bone mineralization
B) Decreased bone resorption
C) Increased osteoblast activity
D) Increased osteoclast activity
E) Increased survival of osteocytes

Correct Answer:

Verified

Unlock this answer now
Get Access to more Verified Answers free of charge

Access For Free