A 34-Year-Old Male Who Is Being Treated for Acute Leukemia

A 34-year-old male who is being treated for acute leukemia develops oliguria.  His serum creatinine level is 2.7 mg/dL.  Renal biopsy reveals multiple uric acid crystals obstructing renal tubular lumen.  The principal site of uric acid precipitation would be which of the following?

A) Proximal tubules due to high solute concentration
B) Proximal tubules due to impaired uric acid transport
C) Loop of Henle due to urine hyposmolarity
D) Distal tubules due to high urine flow rate
E) Collecting ducts due to low urine pH

Correct Answer:

Verified

Unlock this answer now
Get Access to more Verified Answers free of charge

Access For Free