A 14-Year-Old Girl with Sickle Cell Disease Is Admitted to the Hospital

A 14-year-old girl with sickle cell disease is admitted to the hospital due to fever for 2 days.  Temperature is 38 C (100.4 F) , blood pressure is 120/80 mm Hg, pulse is 120/min, and respirations are 18/min.  Examination shows no abnormalities.  Laboratory studies reveal: Blood cultures are obtained, and appropriate pharmacotherapy is initiated.  Her peripheral blood smear is shown in the exhibit.  The smear findings indicated by the arrow most likely reflect which of the following processes?

A) Bone marrow suppression
B) Intracellular parasitic infection
C) Leukemic infiltration
D) Splenic dysfunction
E) Toxic granulations

Correct Answer:

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