Biochemists Identify a Mutation Affecting the Trypsinogen Molecule That Disrupts

Biochemists identify a mutation affecting the trypsinogen molecule that disrupts a critical site on the protein involved in inhibiting the active trypsin moiety.  This mutation prevents trypsin from being permanently inactivated by enzymatic cleavage.  Patients with this mutation would most likely suffer from which of the following conditions?

A) Gastric cancer
B) Liver cirrhosis
C) Megaloblastic anemia
D) Pancreatitis
E) Peptic ulcer

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