A 64-Year-Old Man Is Brought to the Emergency Department Due

A 64-year-old man is brought to the emergency department due to severe chest pain, diaphoresis, and shortness of breath.  Symptoms began suddenly on awakening and have worsened over the past 2 hours.  Blood pressure is 150/90 mm Hg and pulse is 102/min.  Physical examination reveals an S4.  ECG shows ST-segment depression and T-wave inversion in the lateral leads.  Coronary angiography reveals a ruptured atherosclerotic plaque, with a thrombus in the left circumflex artery that causes near-total occlusion.  Normal endothelial cells surrounding the lesion have released large amounts of a chemical substance that help decrease thrombus propagation by inhibiting platelet aggregation.  Which of the following substances was most likely secreted by these endothelial cells?

A) Hageman factor
B) Kallikrein
C) Prostacyclin
D) Protein C
E) Serotonin
F) Thromboxane A2

Correct Answer:

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