A Research Scientist Injects Hepatocellular Carcinoma Cells into the Liver

A research scientist injects hepatocellular carcinoma cells into the liver parenchyma of an experimental guinea pig.  Serial observations show that the tumor cells progressively proliferate and invade the liver parenchyma to form a large mass.  After some time, malignant cells begin to penetrate the vascular basement membrane to gain access to the circulation.  During the process of basement membrane invasion, expression of which of the following substances is most likely to be increased in the tumor cells?

A) Acid hydrolase
B) Alkaline phosphatase
C) Carboxypeptidase
D) E-cadherin
E) Hyaluronic acid
F) Metalloproteinase

Correct Answer:

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