An 18-Year-Old Man Is Evaluated Due to 3 Months of Lower

An 18-year-old man is evaluated due to 3 months of lower extremity pain.  The pain is persistent and present both day and night.  He has no fever, chills, or history of leg trauma.  Imaging shows an expansile lesion of the distal femur.  Surgical resection is performed, and the specimen is shown below. Mutations involving which of the following genes are most likely present in this patient?

A) BRAF
B) HER2
C) KRAS
D) RB1
E) RET

Correct Answer:

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