A 67-Year-Old Man Comes to the Office Due to Severe

A 67-year-old man comes to the office due to severe fatigue for the past several months.  The patient cannot eat as much as he used to and has lost nearly 10 kg (22 lb) in the past 6 months.  Physical examination shows mucosal pallor, hepatomegaly, and massive splenomegaly.  Further evaluation reveals a gain-of-function mutation of a non-receptor tyrosine kinase protein in hematopoietic cells, leading to persistent activation of signal transducers and activators of transcription (STAT) proteins.  This patient is most likely suffering from which of the following disorders?

A) Acute promyelocytic leukemia
B) Chronic lymphocytic leukemia
C) High-grade non-Hodgkin lymphoma
D) Mantle cell lymphoma
E) Primary myelofibrosis

Correct Answer:

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