A 67-Year-Old Man Comes to the Office for a Routine

A 67-year-old man comes to the office for a routine health maintenance evaluation.  He feels well and has no specific symptoms.  Vital signs are within normal limits.  Digital rectal examination reveals a firm prostatic nodule.  The patient undergoes transrectal prostate biopsy, and microscopy reveals sheets of tumor cells infiltrating the stroma with no glandular differentiation; the tumor cells have large vesicular nuclei and prominent nucleoli.  Imaging shows enlargement of several iliac lymph nodes.  Which of the following is the best description of this patient's tumor?

A) Higher-Gleason score and higher stage
B) Higher-Gleason score and lower-stage
C) Lower-Gleason score and higher-stage
D) Lower-Gleason score and lower-stage

Correct Answer:

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