A 16-Year-Old Previously Healthy Boy Is Brought to the Office

A 16-year-old previously healthy boy is brought to the office due to fever, malaise, and sore throat.  The patient says that he gets tired even by simply getting out of bed.  Physical examination shows palatal petechiae, cervical lymphadenopathy, and splenomegaly.  His peripheral blood smear is shown in the image below. Horse erythrocytes agglutinate when exposed to the patient's serum.  The agent causing this patient's disease is most strongly associated with which of the following malignancies?

A) Acute myeloid leukemia
B) Cervical carcinoma
C) Hepatocellular carcinoma
D) Kaposi sarcoma
E) Mucosa-associated lymphoid tissue tumor
F) Multiple myeloma
G) Nasopharyngeal carcinoma

Correct Answer:

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