A 34-Year-Old Man with an Unremarkable Past Medical History Is

A 34-year-old man with an unremarkable past medical history is evaluated for an enlarged lymph node in his anterior cervical chain that measures 4 cm in diameter.  The patient first felt the lymph node several weeks ago and states that it has been steadily increasing in size.  He is concerned about whether or not he "has cancer."  The patient is referred to a specialist for surgical removal of the enlarged node.  Biopsy reveals abnormal lymph node architecture and numerous lymphocytes.  Which of the following, if present, would be most consistent with malignancy in this patient?

A) Lymphocyte pleomorphism
B) Abundant mitotic figures within the lymph node
C) Nuclear changes in lymphocytes
D) Monoclonal T-cell receptor gene rearrangements
E) Admixture of several lymphoid cell types within the lymph node

Correct Answer:

Verified

Unlock this answer now
Get Access to more Verified Answers free of charge

Access For Free