A 4-Day-Old Newborn Is Brought to the Office for a 2-Day

A 4-day-old newborn is brought to the office for a 2-day history of progressive jaundice.  He was born at term following an uncomplicated vaginal delivery.  The patient has been breastfed since birth.  Vital signs are normal.  Examination shows scleral icterus and jaundice from the face to the upper abdomen.  Laboratory results are as follows: Which of the following is the most likely explanation for these findings?

A) CD8⁺ T-lymphocyte-mediated hepatocellular injury
B) Decreased beta-glucuronidase activity
C) Deficiency of erythrocyte glucose-6-phosphate dehydrogenase
D) Decreased UDP glucuronosyltransferase activity
E) Fibrous obliteration of the extrahepatic biliary tree

Correct Answer:

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